No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
164 |
6. Filter based on genotype QC (FinnGen only) |
150 |
Control definitions (FinnGen only)
Control exclude
AB1_PROTOZOAL
Extra metadata
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Malaria
based on the number of shared cases.
Similar with more cases:
- Protozoal diseases
- Certain infectious and parasitic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2110 | 834 | 1215 |
| Only index persons | 1820 | 733 | 1087 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.02 | 0.03 |
| Only index persons | 0.04 | 0.03 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 35.94 | 35.12 | 36.67 |
| Only index persons | 35.61 | 34.39 | 36.42 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 150 | 76 | 74 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.04 |
| Median age at first event (years) | 37.53 | 34.48 | 40.66 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint AB1_MALARIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_MALARIA | 2.107 [1.54, 2.88] | < 0.001 |
| Birth year | 1.002 [0.99, 1.01] | 0.702 |
During the follow-up period (1.1.1998 — 31.12.2019), 94 out of 611 females with AB1_MALARIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_MALARIA | 1.356 [1.05, 1.74] | 0.018 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 85 out of 823 males with AB1_MALARIA died.
Mortality risk
Mortality risk for people of age
years, who have AB1_MALARIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.239% | 0.241% |
| 5 | 1.427% | 1.494% |
| 10 | 3.723% | 3.803% |
| 15 | 7.009% | 7.091% |
| 20 | 12.556% | 12.263% |
Relationships between endpoints
↥Index endpoint: AB1_MALARIA – Malaria
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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