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Plasmodium falciparum malaria

EFO Endpoint Browser PheWeb

AB1_MALARIA_FALCIPARIUM

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — B50
  • Hospital discharge: ICD-9 — 084[0]
  • Hospital discharge: ICD-8 — 084[0]
  • Cause of death: ICD-10 — B50
  • Cause of death: ICD-9 — 084[0]
  • Cause of death: ICD-8 — 084[0]

2 out of 7 registries used, show all original rules.

81

4. Check minimum number of events

None

81

5. Include endpoints

None

81

6. Filter based on genotype QC (FinnGen only)

72

Control definitions (FinnGen only)

Control exclude AB1_PROTOZOAL

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1046 394 612
Only index persons 895 341 554
Unadjusted period prevalence (%)
Whole population 0.02 0.01 0.02
Only index persons 0.02 0.01 0.02
Median age at first event (years)
Whole population 38.27 38.30 38.54
Only index persons 37.53 36.68 38.05

-FinnGen-

Key figures

All Female Male
Number of individuals 72 41 31
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 38.65 34.81 43.72

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint AB1_MALARIA_FALCIPARIUM and mortality.

Females

Parameter HR [95% CI] p-value
AB1_MALARIA_FALCIPARIUM 2.699 [1.72, 4.25] < 0.001
Birth year 0.99 [0.98, 1.0] 0.021

During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 275 females with AB1_MALARIA_FALCIPARIUM died.

Males

Parameter HR [95% CI] p-value
AB1_MALARIA_FALCIPARIUM 1.672 [1.18, 2.38] 0.004
Birth year 0.989 [0.98, 1.0] 0.023

During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 432 males with AB1_MALARIA_FALCIPARIUM died.

Mortality risk

Mortality risk for people of age

years, who have AB1_MALARIA_FALCIPARIUM.

N-year risk Females Males
1 0.279% 0.374%
5 1.305% 2.311%
10 3.095% 5.381%
15 5.829% 10.142%
20 10.234% 16.771%

Relationships between endpoints

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Index endpoint: AB1_MALARIA_FALCIPARIUM – Plasmodium falciparum malaria

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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