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Toxoplasmosis

EFO Endpoint Browser PheWeb

AB1_TOXOPLASMOSIS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — B58
  • Hospital discharge: ICD-9 — 130
  • Hospital discharge: ICD-8 — 130
  • Cause of death: ICD-10 — B58
  • Cause of death: ICD-9 — 130
  • Cause of death: ICD-8 — 130

2 out of 7 registries used, show all original rules.

185

4. Check minimum number of events

None

185

5. Include endpoints

None

185

6. Filter based on genotype QC (FinnGen only)

181

Control definitions (FinnGen only)

Control exclude AB1_PROTOZOAL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1599 935 652
Only index persons 1392 844 548
Unadjusted period prevalence (%)
Whole population 0.02 0.03 0.02
Only index persons 0.03 0.03 0.02
Median age at first event (years)
Whole population 31.42 32.08 30.30
Only index persons 30.26 31.16 28.88

-FinnGen-

Key figures

All Female Male
Number of individuals 181 117 64
Unadjusted period prevalence (%) 0.04 0.05 0.03
Median age at first event (years) 34.20 32.08 38.06

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint AB1_TOXOPLASMOSIS and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
AB1_TOXOPLASMOSIS 2.45 [1.73, 3.47] < 0.001
Birth year 0.99 [0.98, 1.0] 0.053

During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 345 males with AB1_TOXOPLASMOSIS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_TOXOPLASMOSIS.

N-year risk Females Males
1 No data 0.459%
5 No data 2.845%
10 No data 7.235%
15 No data 13.855%
20 No data 23.599%

Relationships between endpoints

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Index endpoint: AB1_TOXOPLASMOSIS – Toxoplasmosis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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