This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Type 1 diabetes, wide definition, subgroup 2
T1D_WIDE2
type I diabetes mellitus: A chronic condition characterized by minimal or absent production of insulin by the pancreas.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
1097 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
694 |
6. Filter based on genotype QC (FinnGen only) |
667 |
Control definitions (FinnGen only)
Control exclude
DIABETES_FG
Control conditions
not PANCREATITIS
and not INSULIN_INTER_AND_LONG
and not KELA_DIAB_INSUL
and not INSULIN_SHORTFAST
and not INSULIN_INTER_AND_LONG
and not KELA_DIAB_INSUL
and not INSULIN_SHORTFAST
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Type 1 diabetes, wide definition, subgroup 2
based on the number of shared cases.
Similar with more cases:
- Type 1 diabetes, wide definition
- Sub-endpoint used in defining T1D endpoints
- Insulin, fast-acting or short human
- Insulin medication
- Diabetes, insulin treatment (Kela reimbursement)
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8193 | 3476 | 4409 |
| Only index persons | 2249 | 991 | 1258 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.10 | 0.12 |
| Only index persons | 0.04 | 0.04 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 53.87 | 58.28 | 50.15 |
| Only index persons | 48.96 | 53.50 | 45.38 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 667 | 292 | 375 |
| Unadjusted period prevalence (%) | 0.16 | 0.11 | 0.19 |
| Median age at first event (years) | 55.32 | 55.63 | 55.07 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
Mortality – FinRegistry
↥Association
Association between endpoint T1D_WIDE2 and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| T1D_WIDE2 | 6.681 [5.35, 8.35] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.368 |
During the follow-up period (1.1.1998 — 31.12.2019), 331 out of 651 females with T1D_WIDE2 died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| T1D_WIDE2 | 7.376 [6.0, 9.07] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 592 out of 1001 males with T1D_WIDE2 died.
Mortality risk
Mortality risk for people of age
years, who have T1D_WIDE2.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.619% | 1.217% |
| 5 | 4.152% | 8.264% |
| 10 | 9.596% | 19.66% |
| 15 | 17.983% | 34.211% |
| 20 | 28.735% | 51.143% |
Relationships between endpoints
↥Index endpoint: T1D_WIDE2 – Type 1 diabetes, wide definition, subgroup 2
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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