diabetic ketoacidosis: The metabolic condition resulted from uncontrolled diabetes mellitus, in which the shift of acid-base status of the body toward the acid side because of loss of base or retention of acids other than carbonic acid is accompanied by the accumulation of ketone bodies in body tissues and fluids.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
149 |
3. Check pre-conditions, main-only, mode, registry filtersPre-conditions: EVENT_AGE<40 Registry filters: 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
115 |
6. Filter based on genotype QC (FinnGen only) |
109 |
Control definitions (FinnGen only)
Control exclude
DIABETES_FG
Control conditions
not E4_DM2
and not PANCREATITIS
and not INSULIN_INTER_AND_LONG
and not KELA_DIAB_INSUL
and not INSULIN_SHORTFAST
and not PANCREATITIS
and not INSULIN_INTER_AND_LONG
and not KELA_DIAB_INSUL
and not INSULIN_SHORTFAST
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Type 1 diabetes, strict definition, subgroup 2
based on the number of shared cases.
Similar with more cases:
- Type 1 diabetes, wide definition, subgroup 2
- Type 1 diabetes, strict definition
- Type 1 diabetes, strict (exclude DM2)
- Type1 diabetes, definitions combined
- Type 1 diabetes, wide definition
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1340 | 519 | 810 |
| Only index persons | 483 | 167 | 316 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.02 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 13.08 | 10.37 | 14.53 |
| Only index persons | 15.15 | 14.82 | 15.32 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 109 | 49 | 60 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 12.25 | 11.71 | 12.69 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint T1D_STRICT2 and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have T1D_STRICT2.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: T1D_STRICT2 – Type 1 diabetes, strict definition, subgroup 2
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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