This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Type 1 diabetes, wide definition
T1D_WIDE
type I diabetes mellitus: A chronic condition characterized by minimal or absent production of insulin by the pancreas.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
10648 |
6. Filter based on genotype QC (FinnGen only) |
10320 |
Control definitions (FinnGen only)
Control exclude
DIABETES_FG
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Type 1 diabetes, wide definition
based on the number of shared cases.
Similar with more cases:
- Diabetes mellitus
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 66380 | 28645 | 37272 |
| Only index persons | 56753 | 24640 | 32113 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.94 | 0.82 | 1.04 |
| Only index persons | 1.09 | 0.91 | 1.23 |
| Median age at first event (years) | |||
| Whole population | 30.82 | 30.62 | 30.69 |
| Only index persons | 28.59 | 28.25 | 28.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 10320 | 4974 | 5346 |
| Unadjusted period prevalence (%) | 2.33 | 1.95 | 2.68 |
| Median age at first event (years) | 24.99 | 19.61 | 30.00 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
Mortality – FinRegistry
↥Association
Association between endpoint T1D_WIDE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| T1D_WIDE | 2.204 [1.97, 2.46] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.243 |
During the follow-up period (1.1.1998 — 31.12.2019), 1508 out of 13311 females with T1D_WIDE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| T1D_WIDE | 2.037 [1.86, 2.24] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.081 |
During the follow-up period (1.1.1998 — 31.12.2019), 2599 out of 18755 males with T1D_WIDE died.
Mortality risk
Mortality risk for people of age
years, who have T1D_WIDE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.197% | 0.397% |
| 5 | 1.283% | 2.672% |
| 10 | 3.35% | 7.251% |
| 15 | 6.373% | 13.036% |
| 20 | 10.674% | 22.12% |
Relationships between endpoints
↥Index endpoint: T1D_WIDE – Type 1 diabetes, wide definition
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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