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Respiratory and cardiovascular disorders specific to the perinatal period

EFO MESH Endpoint Browser PheWeb

P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — P20-P29
  • Cause of death: ICD-10 — P20-P29

2 out of 7 registries used, show all original rules.

823

4. Check minimum number of events

None

823

5. Include endpoints

823

6. Filter based on genotype QC (FinnGen only)

761

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF4
Parent code in ICD-10 P
Name in latin Perturbationes respiratoriae et cardiovasculares temporis perinatalis specificae

Similar endpoints

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List of similar endpoints to Respiratory and cardiovascular disorders specific to the perinatal period based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 72975 31693 41278
Only index persons 31986 13548 18438
Unadjusted period prevalence (%)
Whole population 1.05 0.91 1.15
Only index persons 0.62 0.50 0.70
Median age at first event (years)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00

-FinnGen-

Key figures

All Female Male
Number of individuals 761 407 354
Unadjusted period prevalence (%) 0.17 0.16 0.18
Median age at first event (years) 0.00 0.00 0.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD and mortality.

Females

Parameter HR [95% CI] p-value
P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD 1.961 [1.64, 2.34] < 0.001
Birth year 0.997 [0.99, 1.01] 0.451

During the follow-up period (1.1.1998 — 31.12.2019), 199 out of 29349 females with P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD died.

Males

Parameter HR [95% CI] p-value
P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD 2.368 [2.05, 2.74] < 0.001
Birth year 0.988 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 279 out of 38142 males with P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD died.

Mortality risk

Mortality risk for people of age

years, who have P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD.

N-year risk Females Males
1 0.176% 0.425%
5 1.096% 2.92%
10 2.92% 7.072%
15 5.676% 12.871%
20 10.052% 21.298%

Relationships between endpoints

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Index endpoint: P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD – Respiratory and cardiovascular disorders specific to the perinatal period

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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