newborn respiratory distress syndrome: Infant acute respiratory distress syndrome is a lung disorder that affects premature infants caused by developmental insufficiency of surfactant production and structural immaturity of the lungs. The symptoms usually appear shortly after birth and may include tachypnea, tachycardia, chest wall retractions (recession), expiratory grunting, nasal flaring and cyanosis during breathing efforts.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
479 |
4. Check minimum number of eventsNone |
479 |
5. Include endpointsNone |
479 |
6. Filter based on genotype QC (FinnGen only) |
445 |
Control definitions (FinnGen only)
Extra metadata
Similar endpoints
↥List of similar endpoints to Respiratory distress of newborn based on the number of shared cases.
Similar with more cases:
- Respiratory and cardiovascular disorders specific to the perinatal period
- Certain conditions originating in the perinatal period
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 49038 | 21114 | 27923 |
Only index persons | 18039 | 7483 | 10556 |
Unadjusted period prevalence (%) | |||
Whole population | 0.70 | 0.60 | 0.78 |
Only index persons | 0.35 | 0.28 | 0.40 |
Median age at first event (years) | |||
Whole population | 0.00 | 0.00 | 0.00 |
Only index persons | 0.00 | 0.00 | 0.00 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 445 | 229 | 216 |
Unadjusted period prevalence (%) | 0.10 | 0.09 | 0.11 |
Median age at first event (years) | 0.00 | 0.00 | 0.00 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint P16_RESPI_DISTR_NEWBO and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
P16_RESPI_DISTR_NEWBO | 1.873 [1.51, 2.32] | < 0.001 |
Birth year | 0.996 [0.99, 1.01] | 0.39 |
During the follow-up period (1.1.1998 — 31.12.2019), 106 out of 19773 females with P16_RESPI_DISTR_NEWBO died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
P16_RESPI_DISTR_NEWBO | 1.898 [1.59, 2.26] | < 0.001 |
Birth year | 0.985 [0.97, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 164 out of 26033 males with P16_RESPI_DISTR_NEWBO died.
Mortality risk
Mortality risk for people of age
years, who have P16_RESPI_DISTR_NEWBO.N-year risk | Females | Males |
---|---|---|
1 | 0.196% | 0.286% |
5 | 1.099% | 1.786% |
10 | 2.779% | 4.573% |
15 | 5.361% | 8.709% |
20 | 9.471% | 14.853% |
Relationships between endpoints
↥Index endpoint: P16_RESPI_DISTR_NEWBO – Respiratory distress of newborn
GWS hits: 1