Respiratory distress of newborn

P16_RESPI_DISTR_NEWBO

newborn respiratory distress syndrome: Infant acute respiratory distress syndrome is a lung disorder that affects premature infants caused by developmental insufficiency of surfactant production and structural immaturity of the lungs. The symptoms usually appear shortly after birth and may include tachypnea, tachycardia, chest wall retractions (recession), expiratory grunting, nasal flaring and cyanosis during breathing efforts.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 P22
  • Cause of death: ICD-10 P22

2 out of 7 registries used, show all original rules.

479

4. Check minimum number of events

None

479

5. Include endpoints

None

479

6. Filter based on genotype QC (FinnGen only)

445

Control definitions (FinnGen only)

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF4
Parent code in ICD-10 P2
Name in latin Dyspnoea neonatalis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 49038 21114 27923
Only index persons 18039 7483 10556
Unadjusted period prevalence (%)
Whole population 0.70 0.60 0.78
Only index persons 0.35 0.28 0.40
Median age at first event (years)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00

-FinnGen-

Key figures

All Female Male
Number of individuals 445 229 216
Unadjusted period prevalence (%) 0.10 0.09 0.11
Median age at first event (years) 0.00 0.00 0.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint P16_RESPI_DISTR_NEWBO and mortality.

Females

Parameter HR [95% CI] p-value
P16_RESPI_DISTR_NEWBO 1.873 [1.51, 2.32] < 0.001
Birth year 0.996 [0.99, 1.01] 0.39

During the follow-up period (1.1.1998 — 31.12.2019), 106 out of 19773 females with P16_RESPI_DISTR_NEWBO died.

Males

Parameter HR [95% CI] p-value
P16_RESPI_DISTR_NEWBO 1.898 [1.59, 2.26] < 0.001
Birth year 0.985 [0.97, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 164 out of 26033 males with P16_RESPI_DISTR_NEWBO died.

Mortality risk

Mortality risk for people of age

years, who have P16_RESPI_DISTR_NEWBO.

N-year risk Females Males
1 0.196% 0.286%
5 1.099% 1.786%
10 2.779% 4.573%
15 5.361% 8.709%
20 9.471% 14.853%

Relationships between endpoints

Index endpoint: P16_RESPI_DISTR_NEWBO – Respiratory distress of newborn

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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