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Pre-eclampsia or eclampsia

DOID EFO Endpoint Browser PheWeb

O15_PRE_OR_ECLAMPSIA

preeclampsia: Preeclampsia is a hypertensive disorder of pregnancy that is characterized by new-onset hypertension with proteinuria presenting after 20 weeks of gestation, and depending on mild or severe forms may initially present with severe headache, visual disturbances, and hyperreflexia.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — O11, O14, O15
  • Hospital discharge: ICD-9 — 642[4-7]
  • Hospital discharge: ICD-8 — 6370[349]|63710|63799|66120
  • Cause of death: ICD-10 — O11, O14, O15
  • Cause of death: ICD-9 — 642[4-7]
  • Cause of death: ICD-8 — 6370[349]|63710|63799|66120

2 out of 7 registries used, show all original rules.

9120

4. Check minimum number of events

None

9120

5. Include endpoints

None

9120

6. Filter based on genotype QC (FinnGen only)

8818

Control definitions (FinnGen only)

Control exclude O15_OEDEM_PROTUR_HYPERT

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF8

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 68905 68905 -
Only index persons 67055 67055 -
Unadjusted period prevalence (%)
Whole population 1.97 1.97 -
Only index persons 2.47 2.47 -
Median age at first event (years)
Whole population - 28.55 -
Only index persons - 28.52 -

-FinnGen-

Key figures

All Female Male
Number of individuals 8818 8818 -
Unadjusted period prevalence (%) 3.46 3.46 -
Median age at first event (years) 28.66 28.66 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint O15_PRE_OR_ECLAMPSIA and mortality.

Females

Parameter HR [95% CI] p-value
O15_PRE_OR_ECLAMPSIA 0.758 [0.63, 0.92] 0.004
Birth year 0.999 [0.99, 1.01] 0.833

During the follow-up period (1.1.1998 — 31.12.2019), 173 out of 28606 females with O15_PRE_OR_ECLAMPSIA died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_PRE_OR_ECLAMPSIA.

N-year risk Females Males
1 0.079% No data
5 0.491% No data
10 1.176% No data
15 2.394% No data
20 4.323% No data

Relationships between endpoints

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Index endpoint: O15_PRE_OR_ECLAMPSIA – Pre-eclampsia or eclampsia

GWS hits: 5

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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