No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleonly females |
265735 |
2. Check conditionsNone |
265735 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
4833 |
4. Check minimum number of eventsNone |
4833 |
5. Include endpoints |
13279 |
6. Filter based on genotype QC (FinnGen only) |
12795 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
First used in FinnGen datafreeze
DF7
Pre-eclampsia or poor fetal growth
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 106315 | 106315 | - |
| Only index persons | 104055 | 104055 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 3.05 | 3.05 | - |
| Only index persons | 3.83 | 3.83 | - |
| Median age at first event (years) | |||
| Whole population | - | 28.82 | - |
| Only index persons | - | 28.80 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 12795 | 12795 | - |
| Unadjusted period prevalence (%) | 5.03 | 5.03 | - |
| Median age at first event (years) | 29.11 | 29.11 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint O15_PREEC_OR_FETGRO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| O15_PREEC_OR_FETGRO | 0.837 [0.72, 0.97] | 0.017 |
| Birth year | 0.999 [0.99, 1.01] | 0.864 |
During the follow-up period (1.1.1998 — 31.12.2019), 408 out of 58076 females with O15_PREEC_OR_FETGRO died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have O15_PREEC_OR_FETGRO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.074% | No data |
| 5 | 0.497% | No data |
| 10 | 1.248% | No data |
| 15 | 2.567% | No data |
| 20 | 4.479% | No data |
Relationships between endpoints
↥Index endpoint: O15_PREEC_OR_FETGRO – Pre-eclampsia or poor fetal growth
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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