preeclampsia: Preeclampsia is a hypertensive disorder of pregnancy that is characterized by new-onset hypertension with proteinuria presenting after 20 weeks of gestation, and depending on mild or severe forms may initially present with severe headache, visual disturbances, and hyperreflexia.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleonly females |
265735 |
2. Check conditionsNone |
265735 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
18889 |
4. Check minimum number of eventsNone |
18889 |
5. Include endpointsNone |
18889 |
6. Filter based on genotype QC (FinnGen only) |
18345 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF3
Pregnancy hypertension
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 146142 | 146142 | - |
| Only index persons | 142533 | 142533 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 4.19 | 4.19 | - |
| Only index persons | 5.24 | 5.24 | - |
| Median age at first event (years) | |||
| Whole population | - | 29.14 | - |
| Only index persons | - | 29.10 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 18345 | 18345 | - |
| Unadjusted period prevalence (%) | 7.20 | 7.20 | - |
| Median age at first event (years) | 29.35 | 29.35 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint O15_HYPTENSPREG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| O15_HYPTENSPREG | 0.694 [0.6, 0.8] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.224 |
During the follow-up period (1.1.1998 — 31.12.2019), 494 out of 73447 females with O15_HYPTENSPREG died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have O15_HYPTENSPREG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.084% | No data |
| 5 | 0.4% | No data |
| 10 | 1.013% | No data |
| 15 | 1.986% | No data |
| 20 | 3.437% | No data |
Relationships between endpoints
↥Index endpoint: O15_HYPTENSPREG – Pregnancy hypertension
GWS hits: 19
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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