preeclampsia: Preeclampsia is a hypertensive disorder of pregnancy that is characterized by new-onset hypertension with proteinuria presenting after 20 weeks of gestation, and depending on mild or severe forms may initially present with severe headache, visual disturbances, and hyperreflexia.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleonly females |
265735 |
2. Check conditionsNone |
265735 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
8471 |
4. Check minimum number of eventsNone |
8471 |
5. Include endpointsNone |
8471 |
6. Filter based on genotype QC (FinnGen only) |
8185 |
Control definitions (FinnGen only)
Control exclude
O15_OEDEM_PROTUR_HYPERT
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5
Parent code in ICD-10
O10-O16
Name in latin
Hypertensio gestationalis cum proteinuria significanti
Similar endpoints
↥List of similar endpoints to
Pre-eclampsia
based on the number of shared cases.
Similar with more cases:
- Pregnancy hypertension
- Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
- Delivery, wide proxy
- Pregnancy, childbirth and the puerperium
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 64134 | 64134 | - |
| Only index persons | 62521 | 62521 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.84 | 1.84 | - |
| Only index persons | 2.30 | 2.30 | - |
| Median age at first event (years) | |||
| Whole population | - | 28.58 | - |
| Only index persons | - | 28.55 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 8185 | 8185 | - |
| Unadjusted period prevalence (%) | 3.21 | 3.21 | - |
| Median age at first event (years) | 28.73 | 28.73 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint O15_PREECLAMPS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| O15_PREECLAMPS | 0.737 [0.61, 0.89] | 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.148 |
During the follow-up period (1.1.1998 — 31.12.2019), 168 out of 27833 females with O15_PREECLAMPS died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have O15_PREECLAMPS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.083% | No data |
| 5 | 0.476% | No data |
| 10 | 1.128% | No data |
| 15 | 2.111% | No data |
| 20 | 3.704% | No data |
Relationships between endpoints
↥Index endpoint: O15_PREECLAMPS – Pre-eclampsia
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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