hypertension: Persistently high systemic arterial blood pressure. Based on multiple readings (blood pressure determination), hypertension is currently defined as when systolic pressure is consistently greater than 140 mm Hg or when diastolic pressure is consistently 90 mm Hg or more.
Pre-existing hypertension complicating pregnancy, childbirth and the puerperium
DOID EFO Endpoint Browser PheWeb
O15_EXIST_HYPERT_COMPLIC
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleonly females |
265735 |
2. Check conditionsNone |
265735 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2918 |
4. Check minimum number of eventsNone |
2918 |
5. Include endpointsNone |
2918 |
6. Filter based on genotype QC (FinnGen only) |
2853 |
Control definitions (FinnGen only)
Control exclude
O15_OEDEM_PROTUR_HYPERT
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF3
Parent code in ICD-10
O10-O16
Name in latin
Hypertensio prae-existens graviditatem, partum et/sive puerperium complicans
Similar endpoints
↥List of similar endpoints to
Pre-existing hypertension complicating pregnancy, childbirth and the puerperium
based on the number of shared cases.
Similar with more cases:
- Pregnancy hypertension
- Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
- Delivery, wide proxy
- Pregnancy, childbirth and the puerperium
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 20952 | 20952 | - |
| Only index persons | 20618 | 20618 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.60 | 0.60 | - |
| Only index persons | 0.76 | 0.76 | - |
| Median age at first event (years) | |||
| Whole population | - | 32.95 | - |
| Only index persons | - | 32.90 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2853 | 2853 | - |
| Unadjusted period prevalence (%) | 1.12 | 1.12 | - |
| Median age at first event (years) | 32.96 | 32.96 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint O15_EXIST_HYPERT_COMPLIC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| O15_EXIST_HYPERT_COMPLIC | 1.054 [0.89, 1.25] | 0.548 |
| Birth year | 0.994 [0.99, 1.0] | 0.175 |
During the follow-up period (1.1.1998 — 31.12.2019), 198 out of 14964 females with O15_EXIST_HYPERT_COMPLIC died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have O15_EXIST_HYPERT_COMPLIC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.086% | No data |
| 5 | 0.485% | No data |
| 10 | 1.409% | No data |
| 15 | 2.639% | No data |
| 20 | 4.928% | No data |
Relationships between endpoints
↥Index endpoint: O15_EXIST_HYPERT_COMPLIC – Pre-existing hypertension complicating pregnancy, childbirth and the puerperium
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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