No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleonly females |
265735 |
2. Check conditionsNone |
265735 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
7974 |
4. Check minimum number of eventsNone |
7974 |
5. Include endpointsNone |
7974 |
6. Filter based on genotype QC (FinnGen only) |
7631 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
First used in FinnGen datafreeze
DF7
Similar endpoints
↥List of similar endpoints to
HSIL lesion of the cervix uteri, vagina or vulva
based on the number of shared cases.
Similar with more cases:
- All dysplastic lesions of the cervix uteri, vagina or vulva
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 57280 | 57280 | - |
| Only index persons | 55872 | 55872 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.64 | 1.64 | - |
| Only index persons | 2.05 | 2.05 | - |
| Median age at first event (years) | |||
| Whole population | - | 35.16 | - |
| Only index persons | - | 35.02 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 7631 | 7631 | - |
| Unadjusted period prevalence (%) | 3.00 | 3.00 | - |
| Median age at first event (years) | 35.59 | 35.59 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_FEMALE_GENITAL_HSIL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_FEMALE_GENITAL_HSIL | 1.321 [1.18, 1.48] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.16 |
During the follow-up period (1.1.1998 — 31.12.2019), 1896 out of 47005 females with N14_FEMALE_GENITAL_HSIL died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have N14_FEMALE_GENITAL_HSIL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.146% | No data |
| 5 | 0.826% | No data |
| 10 | 1.991% | No data |
| 15 | 3.594% | No data |
| 20 | 6.228% | No data |
Relationships between endpoints
↥Index endpoint: N14_FEMALE_GENITAL_HSIL – HSIL lesion of the cervix uteri, vagina or vulva
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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