No definition available.
All dysplastic lesions of the cervix uteri, vagina or vulva
N14_FEMALE_GENITAL_DYSPLASIA_ALL
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleonly females |
265735 |
2. Check conditionsNone |
265735 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
12198 |
4. Check minimum number of eventsNone |
12198 |
5. Include endpointsNone |
12198 |
6. Filter based on genotype QC (FinnGen only) |
11718 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
First used in FinnGen datafreeze
DF7
All dysplastic lesions of the cervix uteri, vagina or vulva
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 86287 | 86287 | - |
| Only index persons | 84042 | 84042 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.47 | 2.47 | - |
| Only index persons | 3.09 | 3.09 | - |
| Median age at first event (years) | |||
| Whole population | - | 35.10 | - |
| Only index persons | - | 34.95 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 11718 | 11718 | - |
| Unadjusted period prevalence (%) | 4.60 | 4.60 | - |
| Median age at first event (years) | 35.64 | 35.64 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_FEMALE_GENITAL_DYSPLASIA_ALL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_FEMALE_GENITAL_DYSPLASIA_ALL | 1.196 [1.08, 1.33] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.073 |
During the follow-up period (1.1.1998 — 31.12.2019), 2759 out of 68239 females with N14_FEMALE_GENITAL_DYSPLASIA_ALL died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have N14_FEMALE_GENITAL_DYSPLASIA_ALL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.13% | No data |
| 5 | 0.683% | No data |
| 10 | 1.712% | No data |
| 15 | 3.213% | No data |
| 20 | 5.647% | No data |
Relationships between endpoints
↥Index endpoint: N14_FEMALE_GENITAL_DYSPLASIA_ALL – All dysplastic lesions of the cervix uteri, vagina or vulva
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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