HSIL lesion of the cervix uteri

N14_CERVICAL_HSIL

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D06, N87.1, N87.2
  • Hospital discharge: ICD-9 6221B|6221C|2331A
  • Cause of death: ICD-10 D06, N87.1, N87.2
  • Cause of death: ICD-9 6221B|6221C|2331A

2 out of 7 registries used, show all original rules.

7298

4. Check minimum number of events

None

7298

5. Include endpoints

None

7298

6. Filter based on genotype QC (FinnGen only)

6977

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF7

Similar endpoints

List of similar endpoints to HSIL lesion of the cervix uteri based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 53171 53171 -
Only index persons 51989 51989 -
Unadjusted period prevalence (%)
Whole population 1.52 1.52 -
Only index persons 1.91 1.91 -
Median age at first event (years)
Whole population - 34.59 -
Only index persons - 34.40 -

-FinnGen-

Key figures

All Female Male
Number of individuals 6977 6977 -
Unadjusted period prevalence (%) 2.74 2.74 -
Median age at first event (years) 35.11 35.11 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint N14_CERVICAL_HSIL and mortality.

Females

Parameter HR [95% CI] p-value
N14_CERVICAL_HSIL 1.314 [1.17, 1.48] < 0.001
Birth year 0.991 [0.98, 1.0] 0.045

During the follow-up period (1.1.1998 — 31.12.2019), 1401 out of 43721 females with N14_CERVICAL_HSIL died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_CERVICAL_HSIL.

N-year risk Females Males
1 0.103% No data
5 0.634% No data
10 1.524% No data
15 3.107% No data
20 5.718% No data

Relationships between endpoints

Index endpoint: N14_CERVICAL_HSIL – HSIL lesion of the cervix uteri

GWS hits: 4

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data