≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Osteoporosis

DOID EFO Endpoint Browser PheWeb

M13_OSTEOPOROSIS

osteoporosis: A condition of reduced bone mass, with decreased cortical thickness and a decrease in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. Osteoporosis is classified as primary (Type 1, postmenopausal osteoporosis; Type 2, age-associated osteoporosis; and idiopathic, which can affect juveniles, premenopausal women, and middle-aged men) and secondary osteoporosis (which results from an identifiable cause of bone mass loss).

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M80, M81, M82*
  • Hospital discharge: ICD-9 — 733[0-1]
  • Hospital discharge: ICD-8 — 7230|72391
  • Cause of death: ICD-10 — M80, M81, M82*
  • Cause of death: ICD-9 — 733[0-1]
  • Cause of death: ICD-8 — 7230|72391

2 out of 7 registries used, show all original rules.

9343

4. Check minimum number of events

None

9343

5. Include endpoints

None

9343

6. Filter based on genotype QC (FinnGen only)

9046

Control definitions (FinnGen only)

Control exclude M13_OSTEOCHONDRO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 100074 81572 18008
Only index persons 85098 69843 15255
Unadjusted period prevalence (%)
Whole population 2.00 2.34 0.50
Only index persons 2.21 2.57 0.58
Median age at first event (years)
Whole population 76.25 77.58 70.28
Only index persons 75.89 77.28 69.49

-FinnGen-

Key figures

All Female Male
Number of individuals 9046 6936 2110
Unadjusted period prevalence (%) 2.34 2.72 1.06
Median age at first event (years) 70.38 70.65 69.47

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

↥

Association

Association between endpoint M13_OSTEOPOROSIS and mortality.

Females

Parameter HR [95% CI] p-value
M13_OSTEOPOROSIS 1.732 [1.57, 1.91] < 0.001
Birth year 0.994 [0.99, 1.0] 0.13

During the follow-up period (1.1.1998 — 31.12.2019), 30376 out of 64674 females with M13_OSTEOPOROSIS died.

Males

Parameter HR [95% CI] p-value
M13_OSTEOPOROSIS 2.621 [2.28, 3.01] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 6563 out of 13929 males with M13_OSTEOPOROSIS died.

Mortality risk

Mortality risk for people of age

years, who have M13_OSTEOPOROSIS.

N-year risk Females Males
1 0.147% 0.499%
5 0.936% 2.828%
10 2.385% 6.999%
15 4.419% 13.229%
20 7.85% 21.529%

Relationships between endpoints

↥

Index endpoint: M13_OSTEOPOROSIS – Osteoporosis

GWS hits: 6

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data