No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
359 |
4. Check minimum number of eventsNone |
359 |
5. Include endpointsNone |
359 |
6. Filter based on genotype QC (FinnGen only) |
346 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Drug-induced osteoporosis
based on the number of shared cases.
Similar with more cases:
- Osteoporosis
- Osteopathies and chondropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2113 | 1359 | 743 |
| Only index persons | 1899 | 1226 | 673 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.02 |
| Only index persons | 0.04 | 0.05 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 64.57 | 67.51 | 59.16 |
| Only index persons | 63.70 | 66.76 | 58.12 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 346 | 232 | 114 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.06 |
| Median age at first event (years) | 62.69 | 62.69 | 62.69 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint DRUGADVERS_OSTEOPO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_OSTEOPO | 2.759 [2.28, 3.34] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.848 |
During the follow-up period (1.1.1998 — 31.12.2019), 395 out of 1151 females with DRUGADVERS_OSTEOPO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_OSTEOPO | 3.158 [2.41, 4.14] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 217 out of 617 males with DRUGADVERS_OSTEOPO died.
Mortality risk
Mortality risk for people of age
years, who have DRUGADVERS_OSTEOPO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.322% | 0.638% |
| 5 | 1.866% | 4.02% |
| 10 | 4.474% | 9.482% |
| 15 | 8.094% | 17.051% |
| 20 | 15.429% | 26.671% |
Relationships between endpoints
↥Index endpoint: DRUGADVERS_OSTEOPO – Drug-induced osteoporosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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