No definition available.
Osteoporosis with pathological fracture (FG)
EFO MESH Endpoint Browser PheWeb
OSTEOPOROSIS_FRACTURE_FG
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
2149 |
6. Filter based on genotype QC (FinnGen only) |
2085 |
Control definitions (FinnGen only)
Control exclude
RHEUMA_ENDPOINTS
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Osteoporosis with pathological fracture (FG)
based on the number of shared cases.
Similar with more cases:
- Osteoporosis
- Osteopathies and chondropathies
- Finngen Rheumatological endpoints
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 21534 | 20719 | 796 |
| Only index persons | 19400 | 18718 | 682 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.57 | 0.59 | 0.02 |
| Only index persons | 0.66 | 0.69 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 78.72 | 79.16 | 67.62 |
| Only index persons | 78.62 | 79.02 | 67.63 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2085 | 1957 | 128 |
| Unadjusted period prevalence (%) | 0.73 | 0.77 | 0.06 |
| Median age at first event (years) | 72.53 | 72.82 | 68.04 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint OSTEOPOROSIS_FRACTURE_FG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| OSTEOPOROSIS_FRACTURE_FG | 1.77 [1.59, 1.97] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.027 |
During the follow-up period (1.1.1998 — 31.12.2019), 8523 out of 17159 females with OSTEOPOROSIS_FRACTURE_FG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| OSTEOPOROSIS_FRACTURE_FG | 4.601 [3.34, 6.34] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.017 |
During the follow-up period (1.1.1998 — 31.12.2019), 329 out of 649 males with OSTEOPOROSIS_FRACTURE_FG died.
Mortality risk
Mortality risk for people of age
years, who have OSTEOPOROSIS_FRACTURE_FG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.094% | 0.95% |
| 5 | 0.856% | 5.507% |
| 10 | 2.284% | 13.243% |
| 15 | 4.261% | 23.395% |
| 20 | 7.661% | 36.97% |
Relationships between endpoints
↥Index endpoint: OSTEOPOROSIS_FRACTURE_FG – Osteoporosis with pathological fracture (FG)
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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