No definition available.
Postmenopausal osteoporosis with pathological fracture
EFO MESH Endpoint Browser PheWeb
OSTPOPATFRCTURE_POSTEMENO
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleonly females |
265735 |
2. Check conditionsNone |
265735 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1767 |
4. Check minimum number of eventsNone |
1767 |
5. Include endpointsNone |
1767 |
6. Filter based on genotype QC (FinnGen only) |
1709 |
Control definitions (FinnGen only)
Control exclude
OSTEOPOROSIS_FRACTURE_FG
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M80
Name in latin
Osteoporosis postmenopausalis cum fractura pathologica
Similar endpoints
↥List of similar endpoints to
Postmenopausal osteoporosis with pathological fracture
based on the number of shared cases.
Similar with more cases:
- Osteoporosis with pathological fracture (FG)
- Osteoporosis
- Osteopathies and chondropathies
- Finngen Rheumatological endpoints
- Diseases of the musculoskeletal system and connective tissue
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 19351 | 19351 | - |
| Only index persons | 17522 | 17522 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.55 | 0.55 | - |
| Only index persons | 0.64 | 0.64 | - |
| Median age at first event (years) | |||
| Whole population | - | 79.64 | - |
| Only index persons | - | 79.50 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1709 | 1709 | - |
| Unadjusted period prevalence (%) | 0.67 | 0.67 | - |
| Median age at first event (years) | 73.67 | 73.67 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint OSTPOPATFRCTURE_POSTEMENO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| OSTPOPATFRCTURE_POSTEMENO | 1.727 [1.55, 1.92] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.258 |
During the follow-up period (1.1.1998 — 31.12.2019), 8086 out of 16030 females with OSTPOPATFRCTURE_POSTEMENO died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have OSTPOPATFRCTURE_POSTEMENO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.188% | No data |
| 5 | 0.901% | No data |
| 10 | 2.339% | No data |
| 15 | 4.592% | No data |
| 20 | 8.454% | No data |
Relationships between endpoints
↥Index endpoint: OSTPOPATFRCTURE_POSTEMENO – Postmenopausal osteoporosis with pathological fracture
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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