Postmenopausal osteoporosis with pathological fracture

OSTPOPATFRCTURE_POSTEMENO

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M80.0
  • Cause of death: ICD-10 M80.0

2 out of 7 registries used, show all original rules.

1767

4. Check minimum number of events

None

1767

5. Include endpoints

None

1767

6. Filter based on genotype QC (FinnGen only)

1709

Control definitions (FinnGen only)

Control exclude OSTEOPOROSIS_FRACTURE_FG

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 M80
Name in latin Osteoporosis postmenopausalis cum fractura pathologica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 19351 19351 -
Only index persons 17522 17522 -
Unadjusted period prevalence (%)
Whole population 0.55 0.55 -
Only index persons 0.64 0.64 -
Median age at first event (years)
Whole population - 79.64 -
Only index persons - 79.50 -

-FinnGen-

Key figures

All Female Male
Number of individuals 1709 1709 -
Unadjusted period prevalence (%) 0.67 0.67 -
Median age at first event (years) 73.67 73.67 -

-FinRegistry-

Age distribution of first events

01020304050607080900k1k2k3k4k5k6k7kAgeIndividuals

-FinnGen-

Age distribution of first events

01020405060708090050100150200250300350400450500550600AgeIndividuals

-FinRegistry-

Year distribution of first events

197019751980198519902000200520102015202020220.0k0.5k1.0k1.5k2.0k2.5k3.0k3.5k4.0k4.5k5.0k5.5kYearIndividuals

-FinnGen-

Year distribution of first events

197019751980198519901995200020052010201520202023050100150200250300350400450500550600YearIndividuals

-FinRegistry-

Cumulative Incidence Function

01020304050607080901000.00.51.01.52.02.53.03.54.0AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

01020304050607080901000.00.51.01.52.02.53.03.54.04.55.0AgeProbability of first incidence (%)

Mortality – FinRegistry

Association

Association between endpoint OSTPOPATFRCTURE_POSTEMENO and mortality.

Females

Parameter HR [95% CI] p-value
OSTPOPATFRCTURE_POSTEMENO 1.727 [1.55, 1.92] < 0.001
Birth year 0.996 [0.99, 1.0] 0.258

During the follow-up period (1.1.1998 — 31.12.2019), 8086 out of 16030 females with OSTPOPATFRCTURE_POSTEMENO died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have OSTPOPATFRCTURE_POSTEMENO.

N-year risk Females Males
1 0.188% No data
5 0.901% No data
10 2.339% No data
15 4.592% No data
20 8.454% No data

Relationships between endpoints

Index endpoint: OSTPOPATFRCTURE_POSTEMENO – Postmenopausal osteoporosis with pathological fracture

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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