Fibroblastic disorders

M13_FIBROBLASTIC

fibroma: A non-metastasizing neoplasm arising from the fibrous tissue. It is characterized by the presence of spindle-shaped fibroblasts.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M72
  • Cause of death: ICD-10 M72

2 out of 7 registries used, show all original rules.

8254

4. Check minimum number of events

None

8254

5. Include endpoints

10055

6. Filter based on genotype QC (FinnGen only)

9695

Control definitions (FinnGen only)

Control exclude M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M70-M79
Name in latin Morbositates fibroblasticae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 77980 31008 46192
Only index persons 66960 28663 38297
Unadjusted period prevalence (%)
Whole population 1.13 0.89 1.29
Only index persons 1.29 1.05 1.46
Median age at first event (years)
Whole population 55.81 53.07 57.59
Only index persons 54.90 52.51 56.68

-FinnGen-

Key figures

All Female Male
Number of individuals 9695 4233 5462
Unadjusted period prevalence (%) 2.27 1.66 2.74
Median age at first event (years) 55.45 51.60 58.44

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint M13_FIBROBLASTIC and mortality.

Females

Parameter HR [95% CI] p-value
M13_FIBROBLASTIC 0.829 [0.75, 0.91] < 0.001
Birth year 0.998 [0.99, 1.01] 0.661

During the follow-up period (1.1.1998 — 31.12.2019), 1835 out of 19038 females with M13_FIBROBLASTIC died.

Males

Parameter HR [95% CI] p-value
M13_FIBROBLASTIC 0.831 [0.77, 0.9] < 0.001
Birth year 0.986 [0.98, 1.0] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 4878 out of 25912 males with M13_FIBROBLASTIC died.

Mortality risk

Mortality risk for people of age

years, who have M13_FIBROBLASTIC.

N-year risk Females Males
1 0.106% 0.16%
5 0.592% 0.89%
10 1.358% 2.386%
15 2.588% 4.416%
20 4.469% 7.739%

Relationships between endpoints

Index endpoint: M13_FIBROBLASTIC – Fibroblastic disorders

GWS hits: 33

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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