fibroma: A non-metastasizing neoplasm arising from the fibrous tissue. It is characterized by the presence of spindle-shaped fibroblasts.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
8254 |
4. Check minimum number of eventsNone |
8254 |
5. Include endpoints |
10055 |
6. Filter based on genotype QC (FinnGen only) |
9695 |
Control definitions (FinnGen only)
Control exclude
M13_SOFTTISSUE
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M70-M79
Name in latin
Morbositates fibroblasticae
Similar endpoints
↥List of similar endpoints to
Fibroblastic disorders
based on the number of shared cases.
Similar with more cases:
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 77980 | 31008 | 46192 |
| Only index persons | 66960 | 28663 | 38297 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.13 | 0.89 | 1.29 |
| Only index persons | 1.29 | 1.05 | 1.46 |
| Median age at first event (years) | |||
| Whole population | 55.81 | 53.07 | 57.59 |
| Only index persons | 54.90 | 52.51 | 56.68 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 9695 | 4233 | 5462 |
| Unadjusted period prevalence (%) | 2.27 | 1.66 | 2.74 |
| Median age at first event (years) | 55.45 | 51.60 | 58.44 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_FIBROBLASTIC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_FIBROBLASTIC | 0.829 [0.75, 0.91] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.661 |
During the follow-up period (1.1.1998 — 31.12.2019), 1835 out of 19038 females with M13_FIBROBLASTIC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_FIBROBLASTIC | 0.831 [0.77, 0.9] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 4878 out of 25912 males with M13_FIBROBLASTIC died.
Mortality risk
Mortality risk for people of age
years, who have M13_FIBROBLASTIC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.106% | 0.16% |
| 5 | 0.592% | 0.89% |
| 10 | 1.358% | 2.386% |
| 15 | 2.588% | 4.416% |
| 20 | 4.469% | 7.739% |
Relationships between endpoints
↥Index endpoint: M13_FIBROBLASTIC – Fibroblastic disorders
GWS hits: 33
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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