Plantar Fibromatosis: A superficial fibromatosis arising from soft tissue of the plantar regions. It is characterized by the presence of spindle-shaped fibroblasts, hypercellularity, and an infiltrative growth pattern.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
6292 |
4. Check minimum number of eventsNone |
6292 |
5. Include endpointsNone |
6292 |
6. Filter based on genotype QC (FinnGen only) |
6078 |
Control definitions (FinnGen only)
Control exclude
M13_SOFTTISSUE
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M72
Name in latin
Fibromatosis aponeurosis palmaris
Similar endpoints
↥List of similar endpoints to
Palmar fascial fibromatosis [Dupuytren]
based on the number of shared cases.
Similar with more cases:
- Fibroblastic disorders
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 52845 | 13652 | 38527 |
| Only index persons | 42616 | 11682 | 30934 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.89 | 0.39 | 1.08 |
| Only index persons | 0.97 | 0.43 | 1.18 |
| Median age at first event (years) | |||
| Whole population | 58.18 | 56.12 | 58.86 |
| Only index persons | 57.32 | 55.27 | 58.10 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 6078 | 1572 | 4506 |
| Unadjusted period prevalence (%) | 1.84 | 0.62 | 2.26 |
| Median age at first event (years) | 58.11 | 54.58 | 59.34 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_DUPUTRYEN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_DUPUTRYEN | 0.83 [0.75, 0.92] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.333 |
During the follow-up period (1.1.1998 — 31.12.2019), 940 out of 5710 females with M13_DUPUTRYEN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_DUPUTRYEN | 0.838 [0.78, 0.9] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.041 |
During the follow-up period (1.1.1998 — 31.12.2019), 4250 out of 20227 males with M13_DUPUTRYEN died.
Mortality risk
Mortality risk for people of age
years, who have M13_DUPUTRYEN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.058% | 0.21% |
| 5 | 0.493% | 1.169% |
| 10 | 1.307% | 2.864% |
| 15 | 2.54% | 5.561% |
| 20 | 4.56% | 9.225% |
Relationships between endpoints
↥Index endpoint: M13_DUPUTRYEN – Palmar fascial fibromatosis [Dupuytren]
GWS hits: 46
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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