Plantar Fibromatosis: A superficial fibromatosis arising from soft tissue of the plantar regions. It is characterized by the presence of spindle-shaped fibroblasts, hypercellularity, and an infiltrative growth pattern.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3689 |
4. Check minimum number of eventsNone |
3689 |
5. Include endpointsNone |
3689 |
6. Filter based on genotype QC (FinnGen only) |
3547 |
Control definitions (FinnGen only)
Control exclude
M13_SOFTTISSUE
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M72
Name in latin
Fibromatosis aponeurosis plantaris
Similar endpoints
↥List of similar endpoints to
Plantar fascial fibromatosis
based on the number of shared cases.
Similar with more cases:
- Fibroblastic disorders
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 23994 | 16633 | 7250 |
| Only index persons | 23287 | 16309 | 6978 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.39 | 0.48 | 0.20 |
| Only index persons | 0.50 | 0.60 | 0.27 |
| Median age at first event (years) | |||
| Whole population | 51.33 | 51.43 | 51.16 |
| Only index persons | 51.20 | 51.33 | 50.90 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3547 | 2613 | 934 |
| Unadjusted period prevalence (%) | 0.88 | 1.03 | 0.47 |
| Median age at first event (years) | 51.79 | 50.84 | 54.45 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_PLANTARFASC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_PLANTARFASC | 0.725 [0.65, 0.81] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.346 |
During the follow-up period (1.1.1998 — 31.12.2019), 750 out of 12861 females with M13_PLANTARFASC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_PLANTARFASC | 0.76 [0.68, 0.86] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 526 out of 5422 males with M13_PLANTARFASC died.
Mortality risk
Mortality risk for people of age
years, who have M13_PLANTARFASC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.086% | 0.12% |
| 5 | 0.548% | 0.792% |
| 10 | 1.163% | 1.983% |
| 15 | 2.185% | 3.903% |
| 20 | 3.84% | 6.696% |
Relationships between endpoints
↥Index endpoint: M13_PLANTARFASC – Plantar fascial fibromatosis
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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