No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
128 |
4. Check minimum number of eventsNone |
128 |
5. Include endpointsNone |
128 |
6. Filter based on genotype QC (FinnGen only) |
125 |
Control definitions (FinnGen only)
Control exclude
M13_SOFTTISSUE
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other fibroblastic disorders
based on the number of shared cases.
Similar with more cases:
- Fibroblastic disorders
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1061 | 528 | 526 |
| Only index persons | 957 | 489 | 468 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 51.89 | 50.70 | 52.89 |
| Only index persons | 50.79 | 49.57 | 52.07 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 125 | 65 | 60 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 50.98 | 47.98 | 54.23 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint M13_FIBROBLASTNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_FIBROBLASTNAS | 1.513 [1.07, 2.14] | 0.019 |
| Birth year | 0.992 [0.98, 1.0] | 0.059 |
During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 333 females with M13_FIBROBLASTNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_FIBROBLASTNAS | 1.146 [0.9, 1.45] | 0.263 |
| Birth year | 0.993 [0.98, 1.0] | 0.158 |
During the follow-up period (1.1.1998 — 31.12.2019), 87 out of 384 males with M13_FIBROBLASTNAS died.
Mortality risk
Mortality risk for people of age
years, who have M13_FIBROBLASTNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.163% | 0.247% |
| 5 | 0.856% | 1.611% |
| 10 | 2.199% | 3.758% |
| 15 | 3.941% | 7.482% |
| 20 | 6.81% | 12.945% |
Relationships between endpoints
↥Index endpoint: M13_FIBROBLASTNAS – Other fibroblastic disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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