No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
4471 |
4. Check minimum number of eventsNone |
4471 |
5. Include endpoints |
6184 |
6. Filter based on genotype QC (FinnGen only) |
5949 |
Control definitions (FinnGen only)
Control exclude
M13_OTHERBONE
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Chondropathies
based on the number of shared cases.
Similar with more cases:
- Other disorders of bone
- Osteopathies and chondropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 59885 | 28016 | 31607 |
| Only index persons | 56069 | 26562 | 29507 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.84 | 0.80 | 0.88 |
| Only index persons | 1.06 | 0.98 | 1.13 |
| Median age at first event (years) | |||
| Whole population | 26.48 | 32.21 | 21.29 |
| Only index persons | 26.15 | 31.83 | 21.03 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 5949 | 3467 | 2482 |
| Unadjusted period prevalence (%) | 1.31 | 1.36 | 1.25 |
| Median age at first event (years) | 35.82 | 37.32 | 33.72 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_CHRONDROPATHIES and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_CHRONDROPATHIES | 1.136 [1.0, 1.29] | 0.054 |
| Birth year | 0.99 [0.98, 1.0] | 0.022 |
During the follow-up period (1.1.1998 — 31.12.2019), 1180 out of 18149 females with M13_CHRONDROPATHIES died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_CHRONDROPATHIES | 0.862 [0.76, 0.97] | 0.017 |
| Birth year | 0.991 [0.98, 1.0] | 0.072 |
During the follow-up period (1.1.1998 — 31.12.2019), 808 out of 17339 males with M13_CHRONDROPATHIES died.
Mortality risk
Mortality risk for people of age
years, who have M13_CHRONDROPATHIES.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.084% | 0.17% |
| 5 | 0.578% | 1.056% |
| 10 | 1.307% | 2.926% |
| 15 | 2.585% | 5.293% |
| 20 | 4.649% | 8.932% |
Relationships between endpoints
↥Index endpoint: M13_CHRONDROPATHIES – Chondropathies
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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