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Juvenile osteochondrosis

DOID EFO Endpoint Browser PheWeb

M13_JUVOSTEOCHONRHIP

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M91, M92
  • Hospital discharge: ICD-9 — 7321X|732[3-6]
  • Hospital discharge: ICD-8 — 72209|7222[8-9]
  • Cause of death: ICD-10 — M91, M92
  • Cause of death: ICD-9 — 7321X|732[3-6]
  • Cause of death: ICD-8 — 72209|7222[8-9]

2 out of 7 registries used, show all original rules.

1214

4. Check minimum number of events

None

1214

5. Include endpoints

None

1214

6. Filter based on genotype QC (FinnGen only)

1174

Control definitions (FinnGen only)

Control exclude M13_OTHERBONE

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 17161 7115 10008
Only index persons 15939 6633 9306
Unadjusted period prevalence (%)
Whole population 0.25 0.20 0.28
Only index persons 0.31 0.24 0.36
Median age at first event (years)
Whole population 14.72 14.39 14.83
Only index persons 14.83 14.62 14.98

-FinnGen-

Key figures

All Female Male
Number of individuals 1174 654 520
Unadjusted period prevalence (%) 0.26 0.26 0.26
Median age at first event (years) 19.50 18.59 20.66

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint M13_JUVOSTEOCHONRHIP and mortality.

Females

Parameter HR [95% CI] p-value
M13_JUVOSTEOCHONRHIP 1.541 [1.25, 1.9] < 0.001
Birth year 0.991 [0.98, 1.0] 0.049

During the follow-up period (1.1.1998 — 31.12.2019), 151 out of 5170 females with M13_JUVOSTEOCHONRHIP died.

Males

Parameter HR [95% CI] p-value
M13_JUVOSTEOCHONRHIP 1.025 [0.85, 1.23] 0.794
Birth year 0.99 [0.98, 1.0] 0.047

During the follow-up period (1.1.1998 — 31.12.2019), 156 out of 6552 males with M13_JUVOSTEOCHONRHIP died.

Mortality risk

Mortality risk for people of age

years, who have M13_JUVOSTEOCHONRHIP.

N-year risk Females Males
1 0.154% 0.218%
5 0.888% 1.206%
10 2.037% 3.102%
15 3.735% 6.01%
20 6.754% 10.274%

Relationships between endpoints

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Index endpoint: M13_JUVOSTEOCHONRHIP – Juvenile osteochondrosis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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