No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
979 |
4. Check minimum number of eventsNone |
979 |
5. Include endpointsNone |
979 |
6. Filter based on genotype QC (FinnGen only) |
945 |
Control definitions (FinnGen only)
Control exclude
M13_OTHERBONE
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M94
Name in latin
Chondromalacia
Similar endpoints
↥List of similar endpoints to
Chondromalacia
based on the number of shared cases.
Similar with more cases:
- Chondropathies
- Other disorders of bone
- Osteopathies and chondropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6397 | 3429 | 2943 |
| Only index persons | 6277 | 3389 | 2888 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.10 | 0.08 |
| Only index persons | 0.12 | 0.12 | 0.11 |
| Median age at first event (years) | |||
| Whole population | 43.93 | 44.37 | 43.45 |
| Only index persons | 43.84 | 44.31 | 43.28 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 945 | 581 | 364 |
| Unadjusted period prevalence (%) | 0.21 | 0.23 | 0.18 |
| Median age at first event (years) | 46.27 | 45.18 | 48.01 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_CHONDROMALACIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_CHONDROMALACIA | 0.686 [0.57, 0.83] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.102 |
During the follow-up period (1.1.1998 — 31.12.2019), 116 out of 3100 females with M13_CHONDROMALACIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_CHONDROMALACIA | 0.576 [0.49, 0.68] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.087 |
During the follow-up period (1.1.1998 — 31.12.2019), 161 out of 2662 males with M13_CHONDROMALACIA died.
Mortality risk
Mortality risk for people of age
years, who have M13_CHONDROMALACIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.059% | 0.107% |
| 5 | 0.404% | 0.732% |
| 10 | 0.936% | 1.884% |
| 15 | 1.833% | 3.6% |
| 20 | 3.238% | 6.105% |
Relationships between endpoints
↥Index endpoint: M13_CHONDROMALACIA – Chondromalacia
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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