No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1207 |
4. Check minimum number of eventsNone |
1207 |
5. Include endpointsNone |
1207 |
6. Filter based on genotype QC (FinnGen only) |
1143 |
Control definitions (FinnGen only)
Control exclude
M13_OTHERBONE
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M94
Name in latin
Morbus Tietze
Similar endpoints
↥List of similar endpoints to
Chondrocostal junction syndrome [Tietze]
based on the number of shared cases.
Similar with more cases:
- Chondropathies
- Other disorders of bone
- Osteopathies and chondropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9755 | 6794 | 2871 |
| Only index persons | 9164 | 6431 | 2733 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.19 | 0.08 |
| Only index persons | 0.20 | 0.24 | 0.10 |
| Median age at first event (years) | |||
| Whole population | 53.16 | 56.14 | 46.65 |
| Only index persons | 52.20 | 54.94 | 45.75 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1143 | 868 | 275 |
| Unadjusted period prevalence (%) | 0.29 | 0.34 | 0.14 |
| Median age at first event (years) | 54.94 | 54.62 | 55.94 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_TIETZE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_TIETZE | 1.184 [1.03, 1.36] | 0.015 |
| Birth year | 0.996 [0.99, 1.01] | 0.358 |
During the follow-up period (1.1.1998 — 31.12.2019), 704 out of 5082 females with M13_TIETZE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_TIETZE | 1.178 [0.96, 1.44] | 0.113 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 236 out of 2124 males with M13_TIETZE died.
Mortality risk
Mortality risk for people of age
years, who have M13_TIETZE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.131% | 0.197% |
| 5 | 0.686% | 1.305% |
| 10 | 1.56% | 3.212% |
| 15 | 3.269% | 6.432% |
| 20 | 5.964% | 11.041% |
Relationships between endpoints
↥Index endpoint: M13_TIETZE – Chondrocostal junction syndrome [Tietze]
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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