neurodermatitis: an itchy skin disease similar to atopic dermatitis. It tends to result in focal patches—one or many—that are due to frequent rubbing or scratching of the same area over time.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2086 |
4. Check minimum number of eventsNone |
2086 |
5. Include endpoints |
2182 |
6. Filter based on genotype QC (FinnGen only) |
2104 |
Control definitions (FinnGen only)
Control exclude
L12_DERMATITISECZEMA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L20-L30
Name in latin
Neurodermatitis
Similar endpoints
↥List of similar endpoints to
Lichen simplex chronicus and prurigo
based on the number of shared cases.
Similar with more cases:
- Dermatitis and eczema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 17097 | 9353 | 7639 |
| Only index persons | 15358 | 8556 | 6802 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.24 | 0.27 | 0.21 |
| Only index persons | 0.29 | 0.31 | 0.26 |
| Median age at first event (years) | |||
| Whole population | 56.19 | 56.86 | 55.37 |
| Only index persons | 55.35 | 55.98 | 54.56 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2104 | 1223 | 881 |
| Unadjusted period prevalence (%) | 0.46 | 0.48 | 0.44 |
| Median age at first event (years) | 56.24 | 55.13 | 57.77 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_LICHSIMPANDPRURIGO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_LICHSIMPANDPRURIGO | 1.42 [1.28, 1.58] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.288 |
During the follow-up period (1.1.1998 — 31.12.2019), 1395 out of 7396 females with L12_LICHSIMPANDPRURIGO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_LICHSIMPANDPRURIGO | 1.511 [1.36, 1.68] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.018 |
During the follow-up period (1.1.1998 — 31.12.2019), 1474 out of 6002 males with L12_LICHSIMPANDPRURIGO died.
Mortality risk
Mortality risk for people of age
years, who have L12_LICHSIMPANDPRURIGO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.126% | 0.335% |
| 5 | 0.773% | 1.944% |
| 10 | 1.863% | 4.649% |
| 15 | 3.905% | 8.447% |
| 20 | 7.104% | 14.341% |
Relationships between endpoints
↥Index endpoint: L12_LICHSIMPANDPRURIGO – Lichen simplex chronicus and prurigo
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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