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Other prurigo

EFO MESH Endpoint Browser PheWeb

L12_PRURIGONAS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L28.2
  • Hospital discharge: ICD-9 — 6982A
  • Hospital discharge: ICD-8 — 6982
  • Cause of death: ICD-10 — L28.2
  • Cause of death: ICD-9 — 6982A
  • Cause of death: ICD-8 — 6982

2 out of 7 registries used, show all original rules.

356

4. Check minimum number of events

None

356

5. Include endpoints

None

356

6. Filter based on genotype QC (FinnGen only)

349

Control definitions (FinnGen only)

Control exclude L12_DERMATITISECZEMA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L28
Name in latin Alia prurigo

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2946 1765 1152
Only index persons 2609 1611 998
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.03
Only index persons 0.05 0.06 0.04
Median age at first event (years)
Whole population 55.84 55.10 56.77
Only index persons 54.78 54.34 55.49

-FinnGen-

Key figures

All Female Male
Number of individuals 349 220 129
Unadjusted period prevalence (%) 0.08 0.09 0.06
Median age at first event (years) 55.28 53.27 58.70

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint L12_PRURIGONAS and mortality.

Females

Parameter HR [95% CI] p-value
L12_PRURIGONAS 1.386 [1.18, 1.63] < 0.001
Birth year 0.995 [0.99, 1.0] 0.214

During the follow-up period (1.1.1998 — 31.12.2019), 337 out of 1532 females with L12_PRURIGONAS died.

Males

Parameter HR [95% CI] p-value
L12_PRURIGONAS 1.635 [1.33, 2.01] < 0.001
Birth year 0.984 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 342 out of 1002 males with L12_PRURIGONAS died.

Mortality risk

Mortality risk for people of age

years, who have L12_PRURIGONAS.

N-year risk Females Males
1 0.094% 0.339%
5 0.64% 1.753%
10 1.935% 4.381%
15 3.65% 8.135%
20 6.816% 13.54%

Relationships between endpoints

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Index endpoint: L12_PRURIGONAS – Other prurigo

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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