No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
771 |
4. Check minimum number of eventsNone |
771 |
5. Include endpointsNone |
771 |
6. Filter based on genotype QC (FinnGen only) |
744 |
Control definitions (FinnGen only)
Control exclude
L12_DERMATITISECZEMA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L28
Name in latin
Prurigo nodularis
Similar endpoints
↥List of similar endpoints to
Prurigo nodularis
based on the number of shared cases.
Similar with more cases:
- Lichen simplex chronicus and prurigo
- Dermatitis and eczema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6005 | 3529 | 2437 |
| Only index persons | 5439 | 3242 | 2197 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.10 | 0.07 |
| Only index persons | 0.10 | 0.12 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 62.03 | 62.76 | 60.90 |
| Only index persons | 61.16 | 61.95 | 59.99 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 744 | 460 | 284 |
| Unadjusted period prevalence (%) | 0.17 | 0.18 | 0.14 |
| Median age at first event (years) | 60.92 | 59.73 | 62.85 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_PRURIGONOD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PRURIGONOD | 1.628 [1.43, 1.85] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.366 |
During the follow-up period (1.1.1998 — 31.12.2019), 716 out of 2849 females with L12_PRURIGONOD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PRURIGONOD | 1.578 [1.36, 1.83] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 583 out of 1993 males with L12_PRURIGONOD died.
Mortality risk
Mortality risk for people of age
years, who have L12_PRURIGONOD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.155% | 0.343% |
| 5 | 1.021% | 1.905% |
| 10 | 2.627% | 4.714% |
| 15 | 4.688% | 9.11% |
| 20 | 8.065% | 14.938% |
Relationships between endpoints
↥Index endpoint: L12_PRURIGONOD – Prurigo nodularis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data