lichen disease: a long-term skin condition that mainly affects the skin of the genitals. It usually causes itching and white patches to appear on the affected skin.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1139 |
4. Check minimum number of eventsNone |
1139 |
5. Include endpointsNone |
1139 |
6. Filter based on genotype QC (FinnGen only) |
1094 |
Control definitions (FinnGen only)
Control exclude
L12_DERMATITISECZEMA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L28
Name in latin
Lichen simplex chronicus
Similar endpoints
↥List of similar endpoints to
Lichen simplex chronicus
based on the number of shared cases.
Similar with more cases:
- Lichen simplex chronicus and prurigo
- Dermatitis and eczema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8813 | 4491 | 4275 |
| Only index persons | 7913 | 4095 | 3818 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.13 | 0.12 |
| Only index persons | 0.15 | 0.15 | 0.15 |
| Median age at first event (years) | |||
| Whole population | 53.53 | 54.18 | 52.91 |
| Only index persons | 52.84 | 53.38 | 52.26 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1094 | 595 | 499 |
| Unadjusted period prevalence (%) | 0.24 | 0.23 | 0.25 |
| Median age at first event (years) | 53.07 | 51.89 | 54.48 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_LICHENSIMPLEX and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_LICHENSIMPLEX | 1.208 [1.06, 1.38] | 0.004 |
| Birth year | 0.991 [0.98, 1.0] | 0.044 |
During the follow-up period (1.1.1998 — 31.12.2019), 467 out of 3488 females with L12_LICHENSIMPLEX died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_LICHENSIMPLEX | 1.41 [1.25, 1.59] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.022 |
During the follow-up period (1.1.1998 — 31.12.2019), 651 out of 3285 males with L12_LICHENSIMPLEX died.
Mortality risk
Mortality risk for people of age
years, who have L12_LICHENSIMPLEX.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.065% | 0.25% |
| 5 | 0.621% | 1.792% |
| 10 | 1.481% | 4.38% |
| 15 | 2.961% | 8.242% |
| 20 | 5.346% | 13.364% |
Relationships between endpoints
↥Index endpoint: L12_LICHENSIMPLEX – Lichen simplex chronicus
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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