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Alcohol abuse, main dg

Endpoint Browser PheWeb

KRA_PSY_ALCOH_EXMORE

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Main diagnosis only: side diagnoses are not checked.

Registry filters:

  • Hospital discharge: ICD-10 — F10.0
  • Hospital discharge: ICD-9 — 3050A
  • Cause of death: ICD-10 — F10.0
  • Cause of death: ICD-9 — 3050A

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude KRA_PSY_ANYMENTAL

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 F10

Case counts by codes

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FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 86348 25648 60079
Only index persons 73282 23559 49723
Unadjusted period prevalence (%)
Whole population 1.39 0.73 1.68
Only index persons 1.57 0.87 1.90
Median age at first event (years)
Whole population 42.87 38.26 44.73
Only index persons 41.51 36.43 43.92

-FinnGen-

Key figures

All Female Male
Number of individuals 5974 2245 3729
Unadjusted period prevalence (%) 1.50 0.88 1.87
Median age at first event (years) 45.42 38.40 49.65

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint KRA_PSY_ALCOH_EXMORE and mortality.

Females

Parameter HR [95% CI] p-value
KRA_PSY_ALCOH_EXMORE 4.644 [4.1, 5.26] < 0.001
Birth year 0.993 [0.99, 1.0] 0.108

During the follow-up period (1.1.1998 — 31.12.2019), 2783 out of 19292 females with KRA_PSY_ALCOH_EXMORE died.

Males

Parameter HR [95% CI] p-value
KRA_PSY_ALCOH_EXMORE 4.364 [3.95, 4.82] < 0.001
Birth year 0.99 [0.98, 1.0] 0.021

During the follow-up period (1.1.1998 — 31.12.2019), 11149 out of 41091 males with KRA_PSY_ALCOH_EXMORE died.

Mortality risk

Mortality risk for people of age

years, who have KRA_PSY_ALCOH_EXMORE.

N-year risk Females Males
1 0.314% 0.804%
5 2.461% 5.101%
10 6.114% 12.919%
15 10.707% 23.424%
20 18.011% 37.118%

Relationships between endpoints

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Index endpoint: KRA_PSY_ALCOH_EXMORE – Alcohol abuse, main dg

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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