Hepatitis, Alcoholic: INFLAMMATION of the LIVER due to ALCOHOL ABUSE. It is characterized by NECROSIS of HEPATOCYTES, infiltration by NEUTROPHILS, and deposit of MALLORY BODIES. Depending on its severity, the inflammatory lesion may be reversible or progress to LIVER CIRRHOSIS.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
11189 |
4. Check minimum number of eventsNone |
11189 |
5. Include endpointsNone |
11189 |
6. Filter based on genotype QC (FinnGen only) |
10858 |
Control definitions (FinnGen only)
Control exclude
F5_SUBSTANCE
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F10
Similar endpoints
↥List of similar endpoints to
Acute alcohol intoxication
based on the number of shared cases.
Similar with more cases:
- Mental and behavioural disorders due to alcohol
- Alcohol related diseases, tilastokeskus definition
- Mental and behavioural disorders due to psychoactive substance use
- Alcohol related diseases and deaths, all endpoints
- Any mental disorder
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 181212 | 42870 | 135325 |
| Only index persons | 119294 | 34745 | 84549 |
| Unadjusted period prevalence (%) | |||
| Whole population | 3.17 | 1.23 | 3.78 |
| Only index persons | 2.66 | 1.28 | 3.23 |
| Median age at first event (years) | |||
| Whole population | 42.30 | 39.98 | 42.90 |
| Only index persons | 40.40 | 37.72 | 41.50 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 10858 | 3341 | 7517 |
| Unadjusted period prevalence (%) | 3.02 | 1.31 | 3.78 |
| Median age at first event (years) | 43.76 | 38.22 | 46.22 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_ALCOHOLAC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_ALCOHOLAC | 4.298 [3.79, 4.87] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.086 |
During the follow-up period (1.1.1998 — 31.12.2019), 3327 out of 24062 females with F5_ALCOHOLAC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_ALCOHOLAC | 4.396 [3.96, 4.88] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 12453 out of 49674 males with F5_ALCOHOLAC died.
Mortality risk
Mortality risk for people of age
years, who have F5_ALCOHOLAC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.322% | 0.599% |
| 5 | 2.146% | 4.031% |
| 10 | 5.713% | 9.701% |
| 15 | 10.702% | 18.173% |
| 20 | 18.343% | 29.264% |
Relationships between endpoints
↥Index endpoint: F5_ALCOHOLAC – Acute alcohol intoxication
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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