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Chronic periodontitis

EFO Endpoint Browser PheWeb

K11_PERIODON_CHRON

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K05.30, K05.31
  • Hospital discharge: ICD-9 — 5234
  • Hospital discharge: ICD-8 — 5234
  • Cause of death: ICD-10 — K05.30, K05.31
  • Cause of death: ICD-9 — 5234
  • Cause of death: ICD-8 — 5234

2 out of 7 registries used, show all original rules.

5691

4. Check minimum number of events

None

5691

5. Include endpoints

5691

6. Filter based on genotype QC (FinnGen only)

5364

Control definitions (FinnGen only)

Control exclude K11_ORAL

Extra metadata

First used in FinnGen datafreeze DF6

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 37375 15406 21629
Only index persons 34698 14656 20042
Unadjusted period prevalence (%)
Whole population 0.53 0.44 0.60
Only index persons 0.67 0.54 0.77
Median age at first event (years)
Whole population 59.65 60.10 59.44
Only index persons 59.53 59.92 59.25

-FinnGen-

Key figures

All Female Male
Number of individuals 5364 2252 3112
Unadjusted period prevalence (%) 1.28 0.88 1.56
Median age at first event (years) 61.24 59.47 62.53

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_PERIODON_CHRON and mortality.

Females

Parameter HR [95% CI] p-value
K11_PERIODON_CHRON 2.999 [2.66, 3.38] < 0.001
Birth year 0.994 [0.99, 1.0] 0.129

During the follow-up period (1.1.1998 — 31.12.2019), 3040 out of 12606 females with K11_PERIODON_CHRON died.

Males

Parameter HR [95% CI] p-value
K11_PERIODON_CHRON 3.145 [2.8, 3.53] < 0.001
Birth year 0.988 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 5516 out of 17030 males with K11_PERIODON_CHRON died.

Mortality risk

Mortality risk for people of age

years, who have K11_PERIODON_CHRON.

N-year risk Females Males
1 0.321% 0.707%
5 1.559% 3.627%
10 3.983% 9.122%
15 7.904% 16.795%
20 13.411% 27.571%

Relationships between endpoints

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Index endpoint: K11_PERIODON_CHRON – Chronic periodontitis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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