Oral leukoplakia and related diseases, including avohilmo

K11_ORAL_LEUCOPLAC_RELAT_INCLAVO

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 K13.2
  • Hospital discharge: ICD-10 K13.2
  • Cause of death: ICD-10 K13.2

3 out of 7 registries used, show all original rules.

3013

4. Check minimum number of events

None

3013

5. Include endpoints

None

3013

6. Filter based on genotype QC (FinnGen only)

2908

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF7

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 18230 9927 8241
Only index persons 17529 9610 7919
Unadjusted period prevalence (%)
Whole population 0.26 0.28 0.23
Only index persons 0.33 0.35 0.30
Median age at first event (years)
Whole population 59.04 60.99 56.74
Only index persons 58.93 60.83 56.62

-FinnGen-

Key figures

All Female Male
Number of individuals 2908 1665 1243
Unadjusted period prevalence (%) 0.64 0.65 0.62
Median age at first event (years) 60.48 60.15 60.93

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint K11_ORAL_LEUCOPLAC_RELAT_INCLAVO and mortality.

Females

Parameter HR [95% CI] p-value
K11_ORAL_LEUCOPLAC_RELAT_INCLAVO 1.181 [1.06, 1.31] 0.002
Birth year 0.989 [0.98, 1.0] 0.021

During the follow-up period (1.1.1998 — 31.12.2019), 1320 out of 8669 females with K11_ORAL_LEUCOPLAC_RELAT_INCLAVO died.

Males

Parameter HR [95% CI] p-value
K11_ORAL_LEUCOPLAC_RELAT_INCLAVO 1.233 [1.1, 1.38] < 0.001
Birth year 0.986 [0.98, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 1182 out of 6913 males with K11_ORAL_LEUCOPLAC_RELAT_INCLAVO died.

Mortality risk

Mortality risk for people of age

years, who have K11_ORAL_LEUCOPLAC_RELAT_INCLAVO.

N-year risk Females Males
1 0.103% 0.195%
5 0.575% 1.367%
10 1.485% 3.489%
15 2.861% 6.609%
20 4.837% 11.179%

Relationships between endpoints

Index endpoint: K11_ORAL_LEUCOPLAC_RELAT_INCLAVO – Oral leukoplakia and related diseases, including avohilmo

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data