pleural empyema: The presence of pus in the thoracic cavity, between the visceral and parietal pleura. [database_cross_reference: NCIT:P378]
Suppurative and necrotic conditions of lower respiratory tract
DOID EFO Endpoint Browser PheWeb
J10_NECROTIC
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1643 |
4. Check minimum number of eventsNone |
1643 |
5. Include endpoints |
1805 |
6. Filter based on genotype QC (FinnGen only) |
1736 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Suppurative and necrotic conditions of lower respiratory tract
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 18004 | 5053 | 12664 |
| Only index persons | 13269 | 3969 | 9300 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.29 | 0.14 | 0.35 |
| Only index persons | 0.29 | 0.15 | 0.36 |
| Median age at first event (years) | |||
| Whole population | 60.87 | 62.52 | 60.16 |
| Only index persons | 60.11 | 61.41 | 59.55 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1736 | 467 | 1269 |
| Unadjusted period prevalence (%) | 0.52 | 0.18 | 0.64 |
| Median age at first event (years) | 62.79 | 57.79 | 64.63 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint J10_NECROTIC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_NECROTIC | 3.883 [3.25, 4.64] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.033 |
During the follow-up period (1.1.1998 — 31.12.2019), 1239 out of 3243 females with J10_NECROTIC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_NECROTIC | 3.933 [3.44, 4.5] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 3480 out of 7999 males with J10_NECROTIC died.
Mortality risk
Mortality risk for people of age
years, who have J10_NECROTIC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.415% | 0.674% |
| 5 | 2.186% | 4.328% |
| 10 | 5.092% | 10.557% |
| 15 | 9.762% | 19.553% |
| 20 | 15.875% | 31.206% |
Relationships between endpoints
↥Index endpoint: J10_NECROTIC – Suppurative and necrotic conditions of lower respiratory tract
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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