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Abscess of lung

DOID EFO Endpoint Browser PheWeb

J10_ABSCLUNGPNEUMO

Lung Abscess: Solitary or multiple collections of PUS within the lung parenchyma as a result of infection by bacteria, protozoa, or other agents.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — J85.1, J85.2
  • Hospital discharge: ICD-9 — 5130
  • Hospital discharge: ICD-8 — 51399
  • Cause of death: ICD-10 — J85.1, J85.2
  • Cause of death: ICD-9 — 5130
  • Cause of death: ICD-8 — 51399

2 out of 7 registries used, show all original rules.

472

4. Check minimum number of events

None

472

5. Include endpoints

None

472

6. Filter based on genotype QC (FinnGen only)

449

Control definitions (FinnGen only)

Control exclude J10_NECROTIC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5076 1557 3417
Only index persons 3512 1180 2332
Unadjusted period prevalence (%)
Whole population 0.08 0.04 0.10
Only index persons 0.07 0.04 0.09
Median age at first event (years)
Whole population 60.33 62.79 59.15
Only index persons 58.66 60.67 57.65

-FinnGen-

Key figures

All Female Male
Number of individuals 449 126 323
Unadjusted period prevalence (%) 0.13 0.05 0.16
Median age at first event (years) 60.07 56.66 61.40

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint J10_ABSCLUNGPNEUMO and mortality.

Females

Parameter HR [95% CI] p-value
J10_ABSCLUNGPNEUMO 4.25 [3.11, 5.8] < 0.001
Birth year 0.992 [0.98, 1.0] 0.069

During the follow-up period (1.1.1998 — 31.12.2019), 385 out of 944 females with J10_ABSCLUNGPNEUMO died.

Males

Parameter HR [95% CI] p-value
J10_ABSCLUNGPNEUMO 4.708 [3.8, 5.83] < 0.001
Birth year 0.988 [0.98, 1.0] 0.018

During the follow-up period (1.1.1998 — 31.12.2019), 890 out of 2011 males with J10_ABSCLUNGPNEUMO died.

Mortality risk

Mortality risk for people of age

years, who have J10_ABSCLUNGPNEUMO.

N-year risk Females Males
1 0.272% 1.001%
5 1.99% 5.415%
10 5.023% 14.01%
15 10.22% 24.788%
20 16.725% 38.003%

Relationships between endpoints

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Index endpoint: J10_ABSCLUNGPNEUMO – Abscess of lung

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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