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Pyothorax

DOID EFO Endpoint Browser PheWeb

J10_PYOTHORAX

pleural empyema: The presence of pus in the thoracic cavity, between the visceral and parietal pleura. [database_cross_reference: NCIT:P378]

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — J86
  • Hospital discharge: ICD-9 — 510
  • Hospital discharge: ICD-8 — 510
  • Cause of death: ICD-10 — J86
  • Cause of death: ICD-9 — 510
  • Cause of death: ICD-8 — 510

2 out of 7 registries used, show all original rules.

1362

4. Check minimum number of events

None

1362

5. Include endpoints

None

1362

6. Filter based on genotype QC (FinnGen only)

1317

Control definitions (FinnGen only)

Control exclude J10_NECROTIC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 J85-J86
Name in latin Empyema

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 13230 3541 9495
Only index persons 10093 2856 7237
Unadjusted period prevalence (%)
Whole population 0.22 0.10 0.27
Only index persons 0.23 0.10 0.28
Median age at first event (years)
Whole population 60.81 62.09 60.28
Only index persons 60.34 61.54 59.86

-FinnGen-

Key figures

All Female Male
Number of individuals 1317 345 972
Unadjusted period prevalence (%) 0.40 0.14 0.49
Median age at first event (years) 63.22 58.12 65.03

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint J10_PYOTHORAX and mortality.

Females

Parameter HR [95% CI] p-value
J10_PYOTHORAX 4.032 [3.31, 4.91] < 0.001
Birth year 0.997 [0.99, 1.0] 0.41

During the follow-up period (1.1.1998 — 31.12.2019), 849 out of 2351 females with J10_PYOTHORAX died.

Males

Parameter HR [95% CI] p-value
J10_PYOTHORAX 3.84 [3.31, 4.46] < 0.001
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 2609 out of 6157 males with J10_PYOTHORAX died.

Mortality risk

Mortality risk for people of age

years, who have J10_PYOTHORAX.

N-year risk Females Males
1 0.404% 0.883%
5 2.062% 4.708%
10 5.766% 11.005%
15 10.873% 20.134%
20 18.61% 31.389%

Relationships between endpoints

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Index endpoint: J10_PYOTHORAX – Pyothorax

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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