rheumatic fever: Rheumatic fever (RF) is a multisystem inflammatory disease occurring as a post-infectious, nonsuppurative sequela of untreated streptococcus pyogenes (Group A streptococcus [GAS]) pharyngitis, and mainly occurs in individuals aged 5 to 15 years. The most common presenting signs are fever, migratory polyarthritis and carditis.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
1170 |
6. Filter based on genotype QC (FinnGen only) |
1117 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Rheumatic fever incl heart disease
based on the number of shared cases.
Similar with more cases:
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Cardiovascular diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 20505 | 10490 | 9486 |
| Only index persons | 9214 | 4842 | 4372 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.29 | 0.30 | 0.27 |
| Only index persons | 0.17 | 0.18 | 0.17 |
| Median age at first event (years) | |||
| Whole population | 61.81 | 65.18 | 57.95 |
| Only index persons | 51.22 | 55.20 | 46.81 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1117 | 504 | 613 |
| Unadjusted period prevalence (%) | 0.26 | 0.20 | 0.31 |
| Median age at first event (years) | 51.85 | 47.13 | 55.73 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_RHEUFEV and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_RHEUFEV | 2.108 [1.91, 2.33] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.153 |
During the follow-up period (1.1.1998 — 31.12.2019), 1814 out of 3349 females with I9_RHEUFEV died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_RHEUFEV | 1.918 [1.69, 2.18] | < 0.001 |
| Birth year | 0.984 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1381 out of 2720 males with I9_RHEUFEV died.
Mortality risk
Mortality risk for people of age
years, who have I9_RHEUFEV.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.123% | 0.234% |
| 5 | 0.939% | 1.818% |
| 10 | 2.767% | 4.92% |
| 15 | 5.439% | 8.981% |
| 20 | 9.551% | 15.703% |
Relationships between endpoints
↥Index endpoint: I9_RHEUFEV – Rheumatic fever incl heart disease
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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