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Rheumatic valve diseases

DOID EFO Endpoint Browser PheWeb

I9_RHEUVALV

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I05, I06, I07, I08
  • Hospital discharge: ICD-9 — 39[4-6]
  • Hospital discharge: ICD-8 — 3940|3950|3960|3970
  • Cause of death: ICD-10 — I05, I06, I07, I08
  • Cause of death: ICD-9 — 39[4-6]
  • Cause of death: ICD-8 — 3940|3950|3960|3970

2 out of 7 registries used, show all original rules.

848

4. Check minimum number of events

None

848

5. Include endpoints

None

848

6. Filter based on genotype QC (FinnGen only)

800

Control definitions (FinnGen only)

Control exclude I9_RHEUFEV

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 16608 8594 7551
Only index persons 6507 3468 3039
Unadjusted period prevalence (%)
Whole population 0.24 0.25 0.21
Only index persons 0.12 0.13 0.12
Median age at first event (years)
Whole population 64.36 67.55 60.72
Only index persons 57.15 61.05 52.70

-FinnGen-

Key figures

All Female Male
Number of individuals 800 340 460
Unadjusted period prevalence (%) 0.19 0.13 0.23
Median age at first event (years) 56.61 51.90 60.10

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint I9_RHEUVALV and mortality.

Females

Parameter HR [95% CI] p-value
I9_RHEUVALV 2.207 [1.98, 2.46] < 0.001
Birth year 0.994 [0.99, 1.0] 0.169

During the follow-up period (1.1.1998 — 31.12.2019), 1537 out of 2635 females with I9_RHEUVALV died.

Males

Parameter HR [95% CI] p-value
I9_RHEUVALV 2.004 [1.75, 2.29] < 0.001
Birth year 0.991 [0.98, 1.0] 0.047

During the follow-up period (1.1.1998 — 31.12.2019), 1155 out of 2107 males with I9_RHEUVALV died.

Mortality risk

Mortality risk for people of age

years, who have I9_RHEUVALV.

N-year risk Females Males
1 0.171% 0.411%
5 1.219% 2.429%
10 2.95% 6.713%
15 5.653% 11.989%
20 10.282% 19.825%

Relationships between endpoints

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Index endpoint: I9_RHEUVALV – Rheumatic valve diseases

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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