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Rheumatic fever with heart involvement

DOID EFO Endpoint Browser PheWeb

I9_RHEUFEVHRT

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I01, I02.0
  • Hospital discharge: ICD-9 — 391
  • Hospital discharge: ICD-8 — 391
  • Cause of death: ICD-10 — I01, I02.0
  • Cause of death: ICD-9 — 391
  • Cause of death: ICD-8 — 391

2 out of 7 registries used, show all original rules.

163

4. Check minimum number of events

None

163

5. Include endpoints

None

163

6. Filter based on genotype QC (FinnGen only)

160

Control definitions (FinnGen only)

Control exclude I9_RHEUFEV

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1875 843 1004
Only index persons 1312 610 702
Unadjusted period prevalence (%)
Whole population 0.03 0.02 0.03
Only index persons 0.02 0.02 0.03
Median age at first event (years)
Whole population 45.88 50.55 41.60
Only index persons 36.70 41.53 32.50

-FinnGen-

Key figures

All Female Male
Number of individuals 160 76 84
Unadjusted period prevalence (%) 0.04 0.03 0.04
Median age at first event (years) 44.89 45.99 43.90

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint I9_RHEUFEVHRT and mortality.

Females

Parameter HR [95% CI] p-value
I9_RHEUFEVHRT 1.944 [1.55, 2.44] < 0.001
Birth year 0.993 [0.98, 1.0] 0.117

During the follow-up period (1.1.1998 — 31.12.2019), 159 out of 399 females with I9_RHEUFEVHRT died.

Males

Parameter HR [95% CI] p-value
I9_RHEUFEVHRT 1.889 [1.43, 2.5] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 139 out of 376 males with I9_RHEUFEVHRT died.

Mortality risk

Mortality risk for people of age

years, who have I9_RHEUFEVHRT.

N-year risk Females Males
1 0.185% 0.435%
5 1.056% 2.189%
10 2.706% 5.49%
15 5.191% 10.508%
20 8.884% 17.473%

Relationships between endpoints

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Index endpoint: I9_RHEUFEVHRT – Rheumatic fever with heart involvement

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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