rheumatic fever: Rheumatic fever (RF) is a multisystem inflammatory disease occurring as a post-infectious, nonsuppurative sequela of untreated streptococcus pyogenes (Group A streptococcus [GAS]) pharyngitis, and mainly occurs in individuals aged 5 to 15 years. The most common presenting signs are fever, migratory polyarthritis and carditis.
Rheumatic fever without mention of heart involvement
DOID EFO Endpoint Browser PheWeb
I9_RHEUFEVWITHOUTHEART
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
114 |
4. Check minimum number of eventsNone |
114 |
5. Include endpointsNone |
114 |
6. Filter based on genotype QC (FinnGen only) |
113 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Rheumatic fever without mention of heart involvement
based on the number of shared cases.
Similar with more cases:
- Rheumatic fever incl heart disease
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Cardiovascular diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1291 | 714 | 563 |
| Only index persons | 971 | 550 | 421 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 36.50 | 39.46 | 32.27 |
| Only index persons | 30.76 | 33.43 | 27.27 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 113 | 61 | 52 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | 27.85 | 28.88 | 26.64 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint I9_RHEUFEVWITHOUTHEART and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_RHEUFEVWITHOUTHEART | 2.023 [1.5, 2.72] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.863 |
During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 253 females with I9_RHEUFEVWITHOUTHEART died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_RHEUFEVWITHOUTHEART | 1.981 [1.33, 2.95] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 180 males with I9_RHEUFEVWITHOUTHEART died.
Mortality risk
Mortality risk for people of age
years, who have I9_RHEUFEVWITHOUTHEART.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.15% | 0.323% |
| 5 | 1.268% | 2.127% |
| 10 | 3.63% | 5.092% |
| 15 | 6.593% | 9.279% |
| 20 | 11.567% | 15.75% |
Relationships between endpoints
↥Index endpoint: I9_RHEUFEVWITHOUTHEART – Rheumatic fever without mention of heart involvement
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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