Heart failure and hypertrophic cardiomyopathy

I9_HEARTFAIL_AND_HYPERTCARDIOM

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

  • I9_HYPERTROCARDMYOP
1301

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

537

6. Filter based on genotype QC (FinnGen only)

517

Control definitions (FinnGen only)

Control conditions not I9_HYPERTROCARDMYOP

Extra metadata

First used in FinnGen datafreeze DF5

Case counts by codes

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3880 1606 2239
Only index persons 3162 1299 1863
Unadjusted period prevalence (%)
Whole population 0.06 0.05 0.06
Only index persons 0.06 0.05 0.07
Median age at first event (years)
Whole population 64.57 67.92 62.15
Only index persons 64.98 68.74 62.35

-FinnGen-

Key figures

All Female Male
Number of individuals 517 191 326
Unadjusted period prevalence (%) 0.13 0.08 0.16
Median age at first event (years) 61.40 63.68 60.06

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint I9_HEARTFAIL_AND_HYPERTCARDIOM and mortality.

Females

Parameter HR [95% CI] p-value
I9_HEARTFAIL_AND_HYPERTCARDIOM 2.312 [1.99, 2.68] < 0.001
Birth year 0.995 [0.99, 1.0] 0.234

During the follow-up period (1.1.1998 — 31.12.2019), 625 out of 1166 females with I9_HEARTFAIL_AND_HYPERTCARDIOM died.

Males

Parameter HR [95% CI] p-value
I9_HEARTFAIL_AND_HYPERTCARDIOM 2.417 [2.08, 2.81] < 0.001
Birth year 0.988 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 885 out of 1729 males with I9_HEARTFAIL_AND_HYPERTCARDIOM died.

Mortality risk

Mortality risk for people of age

years, who have I9_HEARTFAIL_AND_HYPERTCARDIOM.

N-year risk Females Males
1 0.211% 0.397%
5 1.164% 2.836%
10 3.2% 7.472%
15 6.537% 13.271%
20 10.87% 22.039%

Relationships between endpoints

Index endpoint: I9_HEARTFAIL_AND_HYPERTCARDIOM – Heart failure and hypertrophic cardiomyopathy

GWS hits: 5

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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