No definition available.
Heart failure and hypertrophic cardiomyopathy
I9_HEARTFAIL_AND_HYPERTCARDIOM
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
1301 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
537 |
6. Filter based on genotype QC (FinnGen only) |
517 |
Control definitions (FinnGen only)
Extra metadata
Similar endpoints
↥List of similar endpoints to Heart failure and hypertrophic cardiomyopathy based on the number of shared cases.
Similar with more cases:
- Hypertrophic cardiomyopathy
- Cardiomyopathy
- Heart failure, strict
- Heart failure,strict
- Heart failure, not strict
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 3880 | 1606 | 2239 |
Only index persons | 3162 | 1299 | 1863 |
Unadjusted period prevalence (%) | |||
Whole population | 0.06 | 0.05 | 0.06 |
Only index persons | 0.06 | 0.05 | 0.07 |
Median age at first event (years) | |||
Whole population | 64.57 | 67.92 | 62.15 |
Only index persons | 64.98 | 68.74 | 62.35 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 517 | 191 | 326 |
Unadjusted period prevalence (%) | 0.13 | 0.08 | 0.16 |
Median age at first event (years) | 61.40 | 63.68 | 60.06 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_HEARTFAIL_AND_HYPERTCARDIOM and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
I9_HEARTFAIL_AND_HYPERTCARDIOM | 2.312 [1.99, 2.68] | < 0.001 |
Birth year | 0.995 [0.99, 1.0] | 0.234 |
During the follow-up period (1.1.1998 — 31.12.2019), 625 out of 1166 females with I9_HEARTFAIL_AND_HYPERTCARDIOM died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
I9_HEARTFAIL_AND_HYPERTCARDIOM | 2.417 [2.08, 2.81] | < 0.001 |
Birth year | 0.988 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 885 out of 1729 males with I9_HEARTFAIL_AND_HYPERTCARDIOM died.
Mortality risk
Mortality risk for people of age
years, who have I9_HEARTFAIL_AND_HYPERTCARDIOM.N-year risk | Females | Males |
---|---|---|
1 | 0.211% | 0.397% |
5 | 1.164% | 2.836% |
10 | 3.2% | 7.472% |
15 | 6.537% | 13.271% |
20 | 10.87% | 22.039% |
Relationships between endpoints
↥Index endpoint: I9_HEARTFAIL_AND_HYPERTCARDIOM – Heart failure and hypertrophic cardiomyopathy
GWS hits: 5