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Chronic iridocyclitis

DOID EFO Endpoint Browser PheWeb

H7_IRIDOCHRONIC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H20.1
  • Hospital discharge: ICD-9 — 3641
  • Hospital discharge: ICD-8 — 36402
  • Cause of death: ICD-10 — H20.1
  • Cause of death: ICD-9 — 3641
  • Cause of death: ICD-8 — 36402

2 out of 7 registries used, show all original rules.

1786

4. Check minimum number of events

None

1786

5. Include endpoints

None

1786

6. Filter based on genotype QC (FinnGen only)

1710

Control definitions (FinnGen only)

Control exclude H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy 5
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H20
Name in latin Iridocyclitis chronica

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 13764 7914 5767
Only index persons 12320 7123 5197
Unadjusted period prevalence (%)
Whole population 0.20 0.23 0.16
Only index persons 0.24 0.26 0.20
Median age at first event (years)
Whole population 49.41 51.00 47.22
Only index persons 48.33 49.76 46.36

-FinnGen-

Key figures

All Female Male
Number of individuals 1710 1044 666
Unadjusted period prevalence (%) 0.38 0.41 0.33
Median age at first event (years) 50.01 48.54 52.31

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint H7_IRIDOCHRONIC and mortality.

Females

Parameter HR [95% CI] p-value
H7_IRIDOCHRONIC 1.199 [1.07, 1.35] 0.002
Birth year 0.997 [0.99, 1.0] 0.405

During the follow-up period (1.1.1998 — 31.12.2019), 840 out of 5935 females with H7_IRIDOCHRONIC died.

Males

Parameter HR [95% CI] p-value
H7_IRIDOCHRONIC 1.122 [0.98, 1.28] 0.086
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 650 out of 4335 males with H7_IRIDOCHRONIC died.

Mortality risk

Mortality risk for people of age

years, who have H7_IRIDOCHRONIC.

N-year risk Females Males
1 0.159% 0.214%
5 0.73% 1.147%
10 1.839% 2.968%
15 3.65% 5.763%
20 6.237% 9.782%

Relationships between endpoints

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Index endpoint: H7_IRIDOCHRONIC – Chronic iridocyclitis

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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