gout: A condition characterized by painful swelling of the joints, which is caused by deposition of urate crystals.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
96 |
4. Check minimum number of eventsNone |
96 |
5. Include endpointsNone |
96 |
6. Filter based on genotype QC (FinnGen only) |
95 |
Control definitions (FinnGen only)
Control exclude
GOUT
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M10
Name in latin
Alia arthritis urica secundaria
Other secondary gout
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 964 | 358 | 599 |
| Only index persons | 824 | 302 | 522 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.02 |
| Only index persons | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 71.27 | 76.27 | 68.30 |
| Only index persons | 70.71 | 75.58 | 67.90 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 95 | 27 | 68 |
| Unadjusted period prevalence (%) | 0.03 | 0.01 | 0.03 |
| Median age at first event (years) | 67.55 | 63.94 | 68.99 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint GOUT_SCND and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| GOUT_SCND | 2.432 [1.7, 3.49] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.198 |
During the follow-up period (1.1.1998 — 31.12.2019), 157 out of 306 females with GOUT_SCND died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| GOUT_SCND | 3.031 [2.18, 4.21] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 239 out of 515 males with GOUT_SCND died.
Mortality risk
Mortality risk for people of age
years, who have GOUT_SCND.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.272% | 0.647% |
| 5 | 1.404% | 3.526% |
| 10 | 3.392% | 7.938% |
| 15 | 6.578% | 14.883% |
| 20 | 11.242% | 24.572% |
Relationships between endpoints
↥Index endpoint: GOUT_SCND – Other secondary gout
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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