multiple sclerosis: A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
2752 |
4. Check minimum number of eventsNone |
2752 |
5. Include endpointsNone |
2752 |
6. Filter based on genotype QC (FinnGen only) |
2620 |
Control definitions (FinnGen only)
Control exclude
G6_DISSOTH, G6_OTHDEMYEL, G6_ADEM, G6_ENCEPHBACT, G6_ENCEPHOTH
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G35-G37
Name in latin
Sclerosis multiplex
Similar endpoints
↥List of similar endpoints to
MS-disease / Multiple Sclerosis
based on the number of shared cases.
Similar with more cases:
- Demyelinating diseases of the central nervous system
- Autoimmune diseases related-to ILD
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Neurological diseases
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 19836 | 13288 | 6385 |
| Only index persons | 17256 | 11971 | 5285 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.31 | 0.38 | 0.18 |
| Only index persons | 0.37 | 0.44 | 0.20 |
| Median age at first event (years) | |||
| Whole population | 39.19 | 38.69 | 40.18 |
| Only index persons | 38.41 | 38.12 | 39.08 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2620 | 1984 | 636 |
| Unadjusted period prevalence (%) | 0.67 | 0.78 | 0.32 |
| Median age at first event (years) | 38.02 | 36.86 | 41.66 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_MS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MS | 1.952 [1.74, 2.19] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.613 |
During the follow-up period (1.1.1998 — 31.12.2019), 690 out of 8943 females with G6_MS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MS | 1.862 [1.65, 2.1] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 583 out of 4008 males with G6_MS died.
Mortality risk
Mortality risk for people of age
years, who have G6_MS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.221% | 0.428% |
| 5 | 1.32% | 2.309% |
| 10 | 3.478% | 5.606% |
| 15 | 6.353% | 10.683% |
| 20 | 10.966% | 17.637% |
Relationships between endpoints
↥Index endpoint: G6_MS – MS-disease / Multiple Sclerosis
GWS hits: 9
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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