≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Other acute disseminated demyelination

DOID EFO Endpoint Browser PheWeb

G6_DISSOTH

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G36
  • Hospital discharge: ICD-9 — 3410
  • Hospital discharge: ICD-8 — 34101
  • Cause of death: ICD-10 — G36
  • Cause of death: ICD-9 — 3410
  • Cause of death: ICD-8 — 34101

2 out of 7 registries used, show all original rules.

341

4. Check minimum number of events

None

341

5. Include endpoints

None

341

6. Filter based on genotype QC (FinnGen only)

316

Control definitions (FinnGen only)

Control exclude G6_DEMYEL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G35-G37
Name in latin Alia demyelinatio disseminata acuta

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2214 1475 720
Only index persons 2052 1408 644
Unadjusted period prevalence (%)
Whole population 0.03 0.04 0.02
Only index persons 0.04 0.05 0.02
Median age at first event (years)
Whole population 38.77 38.00 40.00
Only index persons 37.80 37.69 38.05

-FinnGen-

Key figures

All Female Male
Number of individuals 316 238 78
Unadjusted period prevalence (%) 0.08 0.09 0.04
Median age at first event (years) 38.28 37.17 41.66

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

↥

Association

Association between endpoint G6_DISSOTH and mortality.

Females

Parameter HR [95% CI] p-value
G6_DISSOTH 2.024 [1.58, 2.6] < 0.001
Birth year 0.996 [0.99, 1.0] 0.361

During the follow-up period (1.1.1998 — 31.12.2019), 114 out of 1346 females with G6_DISSOTH died.

Males

Parameter HR [95% CI] p-value
G6_DISSOTH 2.036 [1.57, 2.63] < 0.001
Birth year 0.988 [0.98, 1.0] 0.018

During the follow-up period (1.1.1998 — 31.12.2019), 94 out of 622 males with G6_DISSOTH died.

Mortality risk

Mortality risk for people of age

years, who have G6_DISSOTH.

N-year risk Females Males
1 0.179% 0.402%
5 1.097% 2.427%
10 3.192% 6.325%
15 6.203% 11.838%
20 10.507% 19.86%

Relationships between endpoints

↥

Index endpoint: G6_DISSOTH – Other acute disseminated demyelination

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data