No definition available.
Other demyelinating diseases of the central nervous system
DOID EFO Endpoint Browser PheWeb
G6_OTHDEMYEL
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1322 |
4. Check minimum number of eventsNone |
1322 |
5. Include endpointsNone |
1322 |
6. Filter based on genotype QC (FinnGen only) |
1272 |
Control definitions (FinnGen only)
Control exclude
G6_DEMYEL
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G35-G37
Name in latin
Alii morbi demyelinantes systematis nervosi centralis
Similar endpoints
↥List of similar endpoints to
Other demyelinating diseases of the central nervous system
based on the number of shared cases.
Similar with more cases:
- Demyelinating diseases of the central nervous system
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Neurological diseases
- Neurological diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8543 | 5445 | 3043 |
| Only index persons | 7717 | 5057 | 2660 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.13 | 0.16 | 0.09 |
| Only index persons | 0.16 | 0.19 | 0.10 |
| Median age at first event (years) | |||
| Whole population | 39.82 | 38.63 | 41.86 |
| Only index persons | 39.14 | 38.08 | 41.15 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1272 | 934 | 338 |
| Unadjusted period prevalence (%) | 0.31 | 0.37 | 0.17 |
| Median age at first event (years) | 39.59 | 38.23 | 43.34 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_OTHDEMYEL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_OTHDEMYEL | 2.092 [1.77, 2.47] | < 0.001 |
| Birth year | 0.994 [0.98, 1.0] | 0.142 |
During the follow-up period (1.1.1998 — 31.12.2019), 246 out of 4099 females with G6_OTHDEMYEL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_OTHDEMYEL | 2.444 [2.08, 2.87] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 304 out of 2166 males with G6_OTHDEMYEL died.
Mortality risk
Mortality risk for people of age
years, who have G6_OTHDEMYEL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.224% | 0.37% |
| 5 | 1.238% | 2.478% |
| 10 | 2.828% | 5.803% |
| 15 | 5.52% | 11.151% |
| 20 | 9.909% | 18.746% |
Relationships between endpoints
↥Index endpoint: G6_OTHDEMYEL – Other demyelinating diseases of the central nervous system
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data