attention deficit hyperactivity disorder: A mental disorder characterized by inattention, easy distraction, careless mistakes and avoidance of tasks that require sustained mental focus. These behaviors can lead to maladaptive consequences in the affected individual's life.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3969 |
4. Check minimum number of eventsNone |
3969 |
5. Include endpointsNone |
3969 |
6. Filter based on genotype QC (FinnGen only) |
3702 |
Control definitions (FinnGen only)
Control exclude
F5_BEHEMOCHILD
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F90
Name in latin
Perturbatio activitatis et attentionis
Similar endpoints
↥List of similar endpoints to
Disturbance of activity and attention
based on the number of shared cases.
Similar with more cases:
- Hyperkinetic disorders
- Hyperkinetic disorders
- Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
- Any mental disorder
- Psychiatric diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 77869 | 25797 | 51869 |
| Only index persons | 66365 | 23316 | 43049 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.21 | 0.74 | 1.45 |
| Only index persons | 1.37 | 0.86 | 1.64 |
| Median age at first event (years) | |||
| Whole population | 13.73 | 19.60 | 10.73 |
| Only index persons | 15.50 | 21.50 | 12.24 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3702 | 2276 | 1426 |
| Unadjusted period prevalence (%) | 0.83 | 0.89 | 0.72 |
| Median age at first event (years) | 29.90 | 31.36 | 27.59 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_ADHD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_ADHD | 2.553 [1.94, 3.36] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.18 |
During the follow-up period (1.1.1998 — 31.12.2019), 97 out of 14996 females with F5_ADHD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_ADHD | 2.559 [2.19, 2.99] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 477 out of 37990 males with F5_ADHD died.
Mortality risk
Mortality risk for people of age
years, who have F5_ADHD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.212% | 0.501% |
| 5 | 1.36% | 3.126% |
| 10 | 3.513% | 7.638% |
| 15 | 6.563% | 14.012% |
| 20 | 11.821% | 22.882% |
Relationships between endpoints
↥Index endpoint: F5_ADHD – Disturbance of activity and attention
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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